Polyclonal Antibody to Phospholipase C Beta 4 (PLCb4) | MyBioSource MBS2033947 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Polyclonal Antibody to Phospholipase C Beta 4 (PLCb4)

catalog :

MBS2033947

quantity :

0.01 mg

price :

110 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot: Sample: Recombinant protein.

product information

catalog number :

MBS2033947

products type :

Antibody

products full name :

Polyclonal Antibody to Phospholipase C Beta 4 (PLCb4)

products short name :

[Phospholipase C Beta 4]

products name syn :

[PI-PLC; Phospholipase C-beta-4; Phosphoinositide phospholipase C-beta-4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4]

other names :

[1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4; phospholipase C beta 4; Phosphoinositide phospholipase C-beta-4; Phospholipase C-beta-4; PLC-beta-4]

products gene name :

[PLCb4]

other gene names :

[PLCB4; PLCB4; ARCND2; PI-PLC; PLC-beta-4]

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

specificity :

The antibody is a Rabbit polyclonal antibody raised against PLCb4. It has been selected for its ability to recognize PLCb4 in immunohistochemical staining and western blotting.

purity :

Antigen-specific Affinity Chromatography

form :

Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol

concentration :

200ug/ml

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 4 degree C for frequent use. Aliquot and store at -20 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

WB; IHC; ICC; IP

app notes :

Western blotting: 0.5-2µg/mL. Immunocytochemistry in formalin fixed cells: 5-20µg/mL. Immunohistochemistry in formalin fixed frozen section: 5-20µg/mL. Immunohistochemistry in paraffin section: 5-20µg/mL. Optimal working dilutions must be determined by end user

image1 heading :

Western Blot (WB)

other info1 :

Source: Polyclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant PLCb4 (Ala2~Gln250) expressed in E.coli

other info2 :

Conjugated Antibody: The APC conjugated antibody version of this item is also available as catalog #MBS2073145

ncbi gi num :

289547589

ncbi acc num :

NP_000924.3

ncbi gb acc num :

NM_000933.3

uniprot acc num :

Q15147

ncbi mol weight :

135,845 Da

ncbi pathways :

Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); African Trypanosomiasis Pathway (194384); African Trypanosomiasis Pathway (194323); Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Calcium Signaling Pathway (83050)

ncbi summary :

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010]

uniprot summary :

PLCB4: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction. Defects in PLCB4 are the cause of auriculocondylar syndrome type 2 (ARCND2). ARCND2 is an autosomal dominant craniofacial malformation syndrome characterized by variable mandibular anomalies, including mild to severe micrognathia, temporomandibular joint ankylosis, cleft palate, and a characteristic ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark (question-mark ear). Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase. Chromosomal Location of Human Ortholog: 20p12.3-p12.2. Cellular Component: cytosol; dendrite; nucleus; postsynaptic density; smooth endoplasmic reticulum. Molecular Function: calcium ion binding; phosphoinositide phospholipase C activity; phospholipase C activity; protein binding; signal transducer activity. Biological Process: G-protein coupled receptor signaling pathway; inositol phosphate metabolic process; lipid catabolic process. Disease: Auriculocondylar Syndrome 2

size1 :

0.01 mg

price1 :

110 USD

size2 :

0.02 mg

price2 :

130

size3 :

0.05 mg

price3 :

175

size4 :

0.1 mg

price4 :

225

size5 :

0.2 mg

price5 :

340

size6 :

1 mg

price6 :

800

more info or order :

MyBioSource product webpage