protein

TCL1A, 1-114aa, Human, Recombinant, E Coli

MBS203392

0.1 mg

255 USD

Recombinant Protein

TCL1A, 1-114aa, Human, Recombinant, E Coli

TCL1A

TCL1; TCL-1; protein p14TCL1; Oncogene TCL1; T-cell leukemia/lymphoma 1A anti TCL1A; P14 TCL1; P14 TCL1 protein; T cell leukemia 1; T cell lymphoma 1; T cell lymphoma 1A; TCL 1 protein; TCL1 oncogene; TCL1 PEN; TCL1A; TCL1A.

T-cell leukemia/lymphoma protein 1A; T-cell leukemia/lymphoma protein 1A; T-cell leukemia/lymphoma protein 1A; T-cell lymphoma-1; oncogene TCL-1; oncogene TCL1; protein p14 TCL1; T-cell leukemia/lymphoma 1A; Oncogene TCL-1; Oncogene TCL1; Protein p14 TCL1

TCL1A

TCL1A; TCL1A; TCL1; TCL1; Oncogene TCL1

TCL1A_HUMAN

114

MAECPTLGEA VTDHPDRLWA WEKFVYLDEK QHAWLPLTIE IKDRLQLRVL LRREDVVLGR PMTPTQIGPS LLPIMWQLYP DGRYRSSDSS FWRLVYHIKI DGVEDMLLEL LPDD

> 90% by SDS-PAGE

Liquid. In 50mM Tris-HCl buffer (pH7.5) containing 10% glycerol

1 mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human

Expression System: E Coli

Signal Transduction

TCL1A, also known as T-cell leukemia/lymphoma 1A, is a protein with a suggested role in intracellular regulation of T cell signaling. TCL1A binds to the pleckstrin homology domain of Akt (protein kinase B) family proteins, which facilitates Akt dimerization and activity. By increasing Akt activity TCL1A may enhance the serine/threonine phosphorylation of major Akt signaling substrates, such as Ikk complex, mTOR, BAD, p70S6 kinase, FOXO transcription factors, and GSK3b. These substrates regulate cellular differentiation, growth, survival, and metabolism. Recombinant TCL1A protein was expressed in E.coli and purified by using conventional chromatography techniques

Herling M., et al. (2006) Leukemia. 20(2):280-5. Hoyer KK., et al. (2005) J Immunol. 175(2):864-73.

148922879

NP_001092195

NM_001098725.1

13.4 kDa (114aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher)

PI3K-Akt Signaling Pathway (692234); PI3K-Akt Signaling Pathway (692979)

Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]

TCL1A: Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity. Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation. Belongs to the TCL1 family. Protein type: Oncoprotein; Protein kinase, regulatory subunit. Chromosomal Location of Human Ortholog: 14q32.1. Cellular Component: endoplasmic reticulum; pronucleus; cell cortex. Molecular Function: protein binding. Biological Process: multicellular organismal development; stem cell maintenance

0.1 mg

255 USD

0.5 mg

535