Calnexin, 21-481aa, Human, Recombinant, E Coli | MyBioSource MBS203389 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Calnexin, 21-481aa, Human, Recombinant, E Coli

catalog :

MBS203389

quantity :

0.1 mg

price :

255 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS203389

products type :

Recombinant Protein

products full name :

Calnexin, 21-481aa, Human, Recombinant, E Coli

products short name :

Calnexin

products name syn :

CNX; IP90; P90; CANX; FLJ26570; Histocompatibility complex class I antigen binding protein p88

other names :

calnexin; Calnexin; calnexin; major histocompatibility complex class I antigen-binding protein p88; calnexin; IP90; Major histocompatibility complex class I antigen-binding protein p88; p90

other gene names :

CANX; CANX; CNX; P90; IP90

uniprot entry name :

CALX_HUMAN

sequence length :

592

sequence :

MHDGHDDDVI DIEDDLDDVI EEVEDSKPDT TAPPSSPKVT YKAPVPTGEV YFADSFDRGT LSGWILSKAK KDDTDDEIAK YDGKWEVEEM KESKLPGDKG LVLMSRAKHH AISAKLNKPF LFDTKPLIVQ YEVNFQNGIE CGGAYVKLLS KTPELNLDQF HDKTPYTIMF GPDKCGEDYK LHFIFRHKNP KTGIYEEKHA KRPDADLKTY FTDKKTHLYT LILNPDNSFE ILVDQSVVNS GNLLNDMTPP VNPSREIEDP EDRKPEDWDE RPKIPDPEAV KPDDWDEDAP AKIPDEEATK PEGWLDDEPE YVPDPDAEKP EDWDEDMDGE WEAPQIANPR CESAPGCGVW QRPVIDNPNY KGKWKPPMID NPSYQGIWKP RKIPNPDFFE DLEPFRMTPF SAIGLELWSM TSDIFFDNFI ICADRRIVDD WANDGWGLKK AADGAAEPGV VGQMIEAAEE RP

purity :

> 90% by SDS - PAGE

form :

Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 1mM DTT and 20% glycerol

concentration :

1 mg/ml (determined by Bradford assay)

storage stability :

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

tested application :

SDS-PAGE

other info1 :

Antigen Species: Human

other info2 :

Expression System: E Coli

products categories :

Heat Shock Proteins

products description :

Calnexin, also known as IP90, p88 and p90, is a member of the calnexin family of molecular chaperones. This protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Recombinant Calnexin protein was expressed in E.coli and purified by using conventional chromatography techniques.

products references :

Wang B., et al. (2009) Immunology. 128(1):43-57. Millar DJ., et al. (2009) Proteomics. 9(9):2355-72.

ncbi gi num :

66933005

ncbi acc num :

NP_001019820

ncbi gb acc num :

NM_001024649.1

ncbi mol weight :

52.5 kDa (462aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher)

ncbi pathways :

Adaptive Immune System Pathway (366160); Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway (366163); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Asparagine N-linked Glycosylation Pathway (161013); Assembly Of Viral Components At The Budding Site Pathway (106084); Calnexin/calreticulin Cycle Pathway (187218); Class I MHC Mediated Antigen Processing Presentation Pathway (366161); Defective ALG1 Causes ALG1-CDG (CDG-1k) Pathway (1127605); Defective ALG11 Causes ALG11-CDG (CDG-1p) Pathway (1127608)

ncbi summary :

This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

uniprot summary :

Calnexin: a calcium-binding protein of the calreticulin family. A type I membrane protein of the endoplasmic reticulum .Interacts with newly synthesized glycoproteins in the endoplasmic reticulum. May act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Endoplasmic reticulum; Calcium-binding. Chromosomal Location of Human Ortholog: 5q35. Cellular Component: dendrite cytoplasm; endoplasmic reticulum membrane; protein complex; smooth endoplasmic reticulum; rough endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum; dendritic spine; cell soma; membrane; axon; melanosome; ribosome. Molecular Function: ionotropic glutamate receptor binding; protein binding; unfolded protein binding; apolipoprotein binding; calcium ion binding; glycoprotein binding; carbohydrate binding. Biological Process: antigen processing and presentation of peptide antigen via MHC class I; cellular protein metabolic process; protein folding; synaptic vesicle endocytosis; protein secretion; antigen processing and presentation of exogenous peptide antigen via MHC class II; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification; aging

size1 :

0.1 mg

price1 :

255 USD

size2 :

0.5 mg

price2 :

535

more info or order :

MyBioSource product webpage