Polyclonal Antibody to ATP Binding Cassette Transporter G5 (ABCG5) | MyBioSource MBS2033842 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Polyclonal Antibody to ATP Binding Cassette Transporter G5 (ABCG5)

catalog :

MBS2033842

quantity :

0.01 mg

price :

110 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot: Sample: Recombinant ABCG5, Mouse.

image 2 :

DAB staining on fromalin fixed paraffin- embedded liver tissue)

product information

catalog number :

MBS2033842

products type :

Antibody

products full name :

Polyclonal Antibody to ATP Binding Cassette Transporter G5 (ABCG5)

products short name :

[ATP Binding Cassette Transporter G5]

products name syn :

[ABC-G5; STSL; Sterolin 1; ATP-binding cassette sub-family G member 5]

other names :

[ATP-binding cassette sub-family G member 5; ATP-binding cassette sub-family G member 5; ATP-binding cassette sub-family G member 5; ATP binding cassette subfamily G member 5; Sterolin-1]

products gene name :

[ABCG5]

other gene names :

[Abcg5; Abcg5; cmp; trac; sterolin-1]

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Mouse

specificity :

The antibody is a Rabbit polyclonal antibody raised against ABCG5. It has been selected for its ability to recognize ABCG5 in immunohistochemical staining and western blotting.

purity :

Antigen-specific Affinity Chromatography

form :

Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol

concentration :

200ug/ml

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 4 degree C for frequent use. Aliquot and store at -20 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

WB; IHC; ICC; IP

app notes :

Western blotting: 0.5-2µg/mL. Immunocytochemistry in formalin fixed cells: 5-20µg/mL. Immunohistochemistry in formalin fixed frozen section: 5-20µg/mL. Immunohistochemistry in paraffin section: 5-20µg/mL. Optimal working dilutions must be determined by end user

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Source: Polyclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant ABCG5 (Asp66~Gly276) expressed in E.coli.

other info2 :

Conjugated Antibody: The APC conjugated antibody version of this item is also available as catalog #MBS2072357

ncbi gi num :

14141178

ncbi acc num :

NP_114090.1

ncbi gb acc num :

NM_031884.2

uniprot acc num :

Q99PE8

ncbi mol weight :

73,244 Da

ncbi pathways :

ABC Transporters Pathway (83232); ABC Transporters Pathway (436); ABC-family Proteins Mediated Transport Pathway (575013); ABCA Transporters In Lipid Homeostasis Pathway (575014); Bile Secretion Pathway (193148); Bile Secretion Pathway (193095); Fat Digestion And Absorption Pathway (194386); Fat Digestion And Absorption Pathway (194324); Lipid Digestion, Mobilization, And Transport Pathway (574755); Metabolism Pathway (574739)

ncbi summary :

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily, and functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. Disruption of this gene in mice results in thrombocytopenia, prolonged bleeding times, anemia, leukopenia, infertility, shortened life span and cardiomyopathy. Mice lacking this gene show symptoms of sitosterolemia. [provided by RefSeq, Nov 2015]

uniprot summary :

ABCG5: Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. Defects in ABCG5 are a cause of sitosterolemia (STSL); also known as phytosterolemia or shellfish sterolemia. It is a rare autosomal recessive disorder characterized by increased intestinal absorption of all sterols including cholesterol, plant and shellfish sterols, and decreased biliary excretion of dietary sterols into bile. Sitosterolemia patients have hypercholesterolemia, very high levels of plant sterols in the plasma, and frequently develop tendon and tuberous xanthomas, accelerated atherosclerosis and premature coronary artery disease. Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family. Chromosomal Location of Human Ortholog: 17 E4 17 55.02 cM. Cellular Component: apical part of cell; apical plasma membrane; ATP-binding cassette (ABC) transporter complex; integral component of membrane; membrane; receptor complex. Molecular Function: ATP binding; ATPase activity; ATPase activity, coupled to transmembrane movement of substances; cholesterol transporter activity; nucleotide binding; protein heterodimerization activity. Biological Process: cholesterol efflux; cholesterol homeostasis; drug transmembrane transport; excretion; intestinal cholesterol absorption; negative regulation of cholesterol absorption; transport

size1 :

0.01 mg

price1 :

110 USD

size2 :

0.02 mg

price2 :

130

size3 :

0.05 mg

price3 :

185

size4 :

0.1 mg

price4 :

230

size5 :

0.2 mg

price5 :

345

size6 :

1 mg

price6 :

825

more info or order :

MyBioSource product webpage