PEBP1, 1-187aa, Human, Recombinant, E Coli | MyBioSource MBS203383 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

PEBP1, 1-187aa, Human, Recombinant, E Coli

catalog :

MBS203383

quantity :

0.1 mg

price :

255 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS203383

products type :

Recombinant Protein

products full name :

PEBP1, 1-187aa, Human, Recombinant, E Coli

products short name :

PEBP1

products name syn :

HCNP; PBP; PEBP; Phosphatidylethanolamine binding protein 1 Hippocampal cholinergic neurostimulating peptide; Neuropolypeptide h3; HCNPpp; PEBP; PEBP 1; PEBP1; Phosphatidylethanolamine binding protein; Prostatic binding protein; R kip; Raf kinase inhibitory protein RKIP.

other names :

phosphatidylethanolamine-binding protein 1 preproprotein; Phosphatidylethanolamine-binding protein 1; phosphatidylethanolamine-binding protein 1; Raf kinase inhibitory protein; epididymis luminal protein 210; epididymis secretory protein Li 34; hippocampal cholinergic neurostimulating peptide; neuropolypeptide h3; prostatic binding protein; prostatic-binding protein; raf kinase inhibitor protein; phosphatidylethanolamine binding protein 1; HCNPpp; Neuropolypeptide h3; Prostatic-binding protein; Raf kinase inhibitor protein; RKIP

products gene name :

PEBP1

other gene names :

PEBP1; PEBP1; PBP; HCNP; PEBP; RKIP; HCNPpp; PEBP-1; HEL-210; HEL-S-34; PBP; PEBP; PEBP-1; RKIP; HCNP

uniprot entry name :

PEBP1_HUMAN

sequence length :

187

sequence :

MPVDLSKWSG PLSLQEVDEQ PQHPLHVTYA GAAVDELGKV LTPTQVKNRP TSISWDGLDS GKLYTLVLTD PDAPSRKDPK YREWHHFLVV NMKGNDISSG TVLSDYVGSG PPKGTGLHRY VWLVYEQDRP LKCDEPILSN RSGDHRGKFK VASFRKKYEL RAPVAGTCYQ AEWDDYVPKL YEQLSGK

purity :

> 95% by SDS - PAGE

form :

Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 1mM DTT, 10% glycerol

concentration :

1 mg/ml (determined by Bradford assay)

storage stability :

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

tested application :

SDS-PAGE

other info1 :

Antigen Species: Human

other info2 :

Expression System: E Coli. Endotoxin: < 1.0 Eu per 1 microgram of protein (determined by LAL method)

products categories :

Proteases & Inhibitors

products description :

Phosphatidylethanolamine binding protein 1 (PEBP1), also known as Raf kinase inhibitor protein (RKIP), is a member of the phosphatidylethanolamine-binding protein family and a serine protease inhibitor which inhibits thrombin, neuropsin. PEBP1 plays a pivotal modulatory role in several protein kinase signaling cascades. Protein kinase C (PKC) phosphorylates PEBP1, resulting in release of Raf-1 and activation of MEK and ERK. Expressed in many tissues, PEBP1 is implicated in the regulation of such physiological processes as membrane biosynthesis, spermatogenesis, neural development, and metastasis suppression. Recombinant human PEBP1 was expressed in E.coli and purified by using conventional chromatography techniques.

products references :

Keller ET., et al. (2004) Biochem Pharmacol. 68(6):1049-53. Park S., et al. (2005) Oncogene. 24(21):3535-40.

ncbi gi num :

4505621

ncbi acc num :

NP_002558

ncbi gb acc num :

NM_002567.2

ncbi mol weight :

21 kDa (187aa), confirmed by MALDI-TOF.

ncbi pathways :

Aurora B Signaling Pathway (138080); EGFR1 Signaling Pathway (198782); ErbB1 Downstream Signaling Pathway (138057); TNF-alpha/NF-kB Signaling Pathway (198884)

ncbi summary :

This gene encodes a member of the phosphatidylethanolamine-binding family of proteins and has been shown to modulate multiple signaling pathways, including the MAP kinase (MAPK), NF-kappa B, and glycogen synthase kinase-3 (GSK-3) signaling pathways. The encoded protein can be further processed to form a smaller cleavage product, hippocampal cholinergic neurostimulating peptide (HCNP), which may be involved in neural development. This gene has been implicated in numerous human cancers and may act as a metastasis suppressor gene. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Jul 2015]

uniprot summary :

RKIP: a metastasis suppressor that regulates extracellular matrix remodeling and tumor survival. Binds to and inhibits Raf-1. Phosphorylation by classic and atypical but not novel PKC isoforms dissociates this complex, relieving inhibition of the Raf/MAP kinase signaling cascade. Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. Cleaved into hippocampal cholinergic neurostimulating peptide (HCMP) that appears to be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Expressed in brain. Increased expression in aged senescence-accelerated mice. Protein type: Lipid-binding; Protein kinase, regulatory subunit. Chromosomal Location of Human Ortholog: 12q24.23. Cellular Component: cytoplasm; nucleus. Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; enzyme binding; phosphatidylethanolamine binding; protein kinase binding; ATP binding

size1 :

0.1 mg

price1 :

255 USD

size2 :

0.5 mg

price2 :

535

more info or order :

MyBioSource product webpage