protein

Calbindin1, 1-261aa, Human, Recombinant, E Coli

MBS203382

0.1 mg

255 USD

Recombinant Protein

Calbindin1, 1-261aa, Human, Recombinant, E Coli

Calbindin1

CAB27; Calbindin D28; D-28K; CALB1; calbindin 1 28kDa; CALB; Calbindin1

calbindin; Calbindin; calbindin; RTVL-H protein; calbindin 1, (28kD); calbindin D28; vitamin D-dependent calcium-binding protein, avian-type; calbindin 1, 28kDa; Calbindin D28; D-28K; Vitamin D-dependent calcium-binding protein, avian-type

CALB1; CALB1; CALB; D-28K; CAB27

CALB1_HUMAN

261

MAESHLQSSL ITASQFFEIW LHFDADGSGY LEGKELQNLI QELQQARKKA GLELSPEMKT FVDQYGQRDD GKIGIVELAH VLPTEENFLL LFRCQQLKSC EEFMKTWRKY DTDHSGFIET EELKNFLKDL LEKANKTVDD TKLAEYTDLM LKLFDSNNDG KLELTEMARL LPVQENFLLK FQGIKMCGKE FNKAFELYDQ DGNGYIDENE LDALLKDLCE KNKQDLDINN ITTYKKNIMA LSDGGKLYRT DLALILCAGD N

> 95% by SDS - PAGE

Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 1mM DTT, 10% glycerol, 2mM EDTA

1 mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human

Expression System: E Coli

Neuroscience

Calbindin 1 is a calcium binding protein belonging to the troponin C superfamily. Calbindin is expressed in neural tissues. It plays an essential role in calcium regulation (including calcium transport and uptake, calcification of bone and teeth) and calcium related signalling in neurons and transiently in embryological development. This calbindin also has a role in protecting neurons from apoptotic cell death. Disregulation of this calbindin protein relates to epilepsy, amyotrophic lateral sclerosis, Huntington's disease. Recombinant human Calbindin1 was expressed in E.coli and purified by using conventional chromatography techniques.

Heizmann CW., et al. (1988) J Cardiovasc Pharmacol. 5:S30-7. Kaqi u., et al. (1988) Cell Tissue Res. 252(2):359-65.

4826655

NP_004920

NM_004929.3

30 kDa (261aa), confirmed by MALDI-TOF.

Endocrine And Other Factor-regulated Calcium Reabsorption Pathway (213307); Endocrine And Other Factor-regulated Calcium Reabsorption Pathway (213276)

The protein encoded by this gene is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. Originally described as a 27 kDa protein, it is now known to be a 28 kDa protein. It contains four active calcium-binding domains, and has two modified domains that are thought to have lost their calcium binding capability. This protein is thought to buffer entry of calcium upon stimulation of glutamate receptors. Depletion of this protein was noted in patients with Huntington disease. [provided by RefSeq, Jan 2015]

CALB1: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3 ,5 -cyclic nucleotide phosphodiesterase. Interacts with RANBP9. Belongs to the calbindin family. Protein type: Calcium-binding. Chromosomal Location of Human Ortholog: 8q21.3. Cellular Component: cell soma; axon; dendrite; synapse; cytosol; nucleus. Molecular Function: vitamin D binding; protein binding; zinc ion binding; calcium ion binding. Biological Process: cytosolic calcium ion homeostasis; long-term memory; short-term memory; regulation of synaptic plasticity; locomotory behavior

0.1 mg

255 USD

0.5 mg

535