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company name :
MyBioSource
product type :
protein
product name :
eIF4E-BP1, 1-118aa, Human, His-tag, Recombinant, E Coli
catalog :
MBS203380
quantity :
0.1 mg
price :
255 USD
more info or order :
product information
catalog number :
MBS203380
products type :
Recombinant Protein
products full name :
eIF4E-BP1, 1-118aa, Human, His-tag, Recombinant, E Coli
products short name :
eIF4E-BP1
products name syn :
4E-BP1; 4EBP1; BP-1; MGC4316; PHAS-I; Eukaryotic translation initiation factor 4E-binding protein 1; EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1; phosphorylated heat- and acid-stable protein regulated by insulin 1
other names :
eukaryotic translation initiation factor 4E-binding protein 1; Eukaryotic translation initiation factor 4E-binding protein 1; eukaryotic translation initiation factor 4E-binding protein 1; eIF4E-binding protein 1; phosphorylated heat- and acid-stable protein regulated by insulin 1; eukaryotic translation initiation factor 4E binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I
products gene name :
eIF4E-BP1
other gene names :
EIF4EBP1; EIF4EBP1; BP-1; 4EBP1; 4E-BP1; PHAS-I; 4E-BP1; eIF4E-binding protein 1; PHAS-I
uniprot entry name :
4EBP1_HUMAN
sequence length :
118
sequence :
MGSSHHHHHH SSGLVPRGSH MSGGSSCSQT PSRAIPATRR VVLGDGVQLP PGDYSTTPGG TLFSTTPGGT RIIYDRKFLM ECRNSPVTKT PPRDLPTIPG VTSPSSDEPP MEASQSHLRN SPEDKRAGGE ESQFEMDI
purity :
> 95% by SDS - PAGE
form :
Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol
concentration :
1 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human. Tag: His-tag
other info2 :
Expression System: E Coli
products categories :
Transcription & Translation
products description :
eIF4E-BP1, also known as eukaryotic translation initiation factor 4E-binding protein 1, is a member of a family of translation repressor proteins. This protein regulates eukaryotic translation initiation factor 4E (eIF4E) activity by preventing its assembly into the eIF4F complex and mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. Recombinant EIF4EBP1 protein was expressed in E.coli and purified by using conventional chromatography techniques.
products references :
Pause A., et al. (1994) Nature. 371:762-767. Olsen JV., et al. (2006) Cell. 127(3):635-48.
ncbi gi num :
4758258
ncbi acc num :
NP_004086
ncbi gb acc num :
NM_004095.3
ncbi mol weight :
14.7 kDa (138aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher)
ncbi pathways :
AMPK Signaling Pathway (198868); AMPK Signaling Pathway (989139); AMPK Signaling Pathway (992181); Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway (105970); Acute Myeloid Leukemia Pathway (83117); Acute Myeloid Leukemia Pathway (529); Alpha6-Beta4 Integrin Signaling Pathway (198807); BDNF Signaling Pathway (712093); Cap-dependent Translation Initiation Pathway (105967); Choline Metabolism In Cancer Pathway (1059539)
ncbi summary :
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]
uniprot summary :
4E-BP1: binds to eIF4E, preventing its assembly into the EIF4F complex and inhibiting cap-dependent translation. Phosphorylation of 4E-BP1 disrupts this binding, activating cap-dependent translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the PI3 kinase pathway. Protein type: Translation initiation; Translation. Chromosomal Location of Human Ortholog: 8p12. Cellular Component: nucleoplasm; protein complex; cytoplasm; cytosol. Molecular Function: protein binding; translation repressor activity; eukaryotic initiation factor 4E binding. Biological Process: negative regulation of translational initiation; cellular protein metabolic process; response to ethanol; TOR signaling pathway; translation; translational initiation; insulin receptor signaling pathway; gene expression; positive regulation of mitotic cell cycle; negative regulation of protein complex assembly; G1/S transition of mitotic cell cycle; lung development
size1 :
0.1 mg
price1 :
255 USD
size2 :
0.5 mg
price2 :
535
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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