protein

OAS1, 1-364aa, Human, His-tag, Recombinant, E Coli

MBS203376

0.1 mg

510 USD

Recombinant Protein

OAS1, 1-364aa, Human, His-tag, Recombinant, E Coli

OAS1

IFI-4; OIAS; OIASI; 2'; 5'-oligoadenylate synthetase 1; isoform2 (2 5')oligo(A) synthetase 1; 2' 5' oligo A synthetase 1; 2 5 Oligoadenylate Synthetase 1; 2 5A synthetase 1; 2' 5' oligoadenylate synthetase 1; 2' 5' oligoisoadenylate synthetase 1; 2'5' oligoadenylate synthetase 1; 2'5' oligoisoadenylate synthetase 1; p46/p42 OAS; 2'5' oligo A synthetase 1; E18/E16; IFI 4; IFI4; OAS 1

2'-5'-oligoadenylate synthase 1 isoform 2; 2'-5'-oligoadenylate synthase 1; 2'-5'-oligoadenylate synthase 1; (2-5')oligo(A) synthase 1; (2-5')oligo(A) synthetase 1; 2',5'-oligo A synthetase 1; 2',5'-oligoadenylate synthetase 1, 40/46kDa; 2'-5' oligoadenylate synthetase 1 p48 isoform; 2'-5' oligoadenylate synthetase 1 p52 isoform; 2'-5'-oligoisoadenylate synthetase 1; 2-5A synthase 1; 2-5A synthetase 1; E18/E16; p46/p42 OAS; 2'-5'-oligoadenylate synthetase 1, 40/46kDa; E18/E16; p46/p42 OAS

OAS1

OAS1; OAS1; OIAS; IFI-4; OIASI; OIAS; (2-5')oligo(A) synthase 1; 2-5A synthase 1

OAS1_HUMAN

364

MGSSHHHHHH SSGLVPRGSH MMDLRNTPAK SLDKFIEDYL LPDTCFRMQI NHAIDIICGF LKERCFRGSS YPVCVSKVVK GGSSGKGTTL RGRSDADLVV FLSPLTTFQD QLNRRGEFIQ EIRRQLEACQ RERAFSVKFE VQAPRWGNPR ALSFVLSSLQ LGEGVEFDVL PAFDALGQLT GSYKPNPQIY VKLIEECTDL QKEGEFSTCF TELQRDFLKQ RPTKLKSLIR LVKHWYQNCK KKLGKLPPQY ALELLTVYAW ERGSMKTHFN TAQGFRTVLE LVINYQQLCI YWTKYYDFKN PIIEKYLRRQ LTKPRPVILD PADPTGNLGG GDPKGWRQLA QEAEAWLNYP CFKNWDGSPV SSWILLVRPP ASSLPFIPAP LHEA

> 95% by SDS-PAGE

Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol and 1mM DTT.

1 mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human. Tag: His-tag

Expression System: E Coli. Endotoxin: < 1.0 Eu per 1 microgram of protein (determined by LAL method)

Enzymes & Proteases

OAS1 is an enzyme included in the 2',5'-oligoadenylate synthase family. This enzyme is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates(2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. OAS1 may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. Recombinant OAS1 protein was expressed in E.coli and purified by using conventional chromatography techniques.

Rios JJ., et al. (2007) BMC Genomics. 8:313. Tessier MC., et al. (2006) J Med Genet. 43(2):129-32.

74229011

NP_002525

NM_002534.2

43.9 kDa (384aa), confirmed by MALDI-TOF.

Cytokine Signaling In Immune System Pathway 366171!!Hepatitis C Pathway 173973!!Hepatitis C Pathway 173907!!Herpes Simplex Infection Pathway 377873!!Herpes Simplex Infection Pathway 377865!!Immune System Pathway 106386!!Influenza A Pathway 217173!!Influenza A Pathway 217150!!Interferon Signaling Pathway 187103!!Interferon Alpha/beta Signaling Pathway 187104

This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

0.1 mg

510 USD