Polyclonal Antibody to Liver X Receptor Beta (LXRb) | MyBioSource MBS2033736 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Polyclonal Antibody to Liver X Receptor Beta (LXRb)

catalog :

MBS2033736

quantity :

0.01 mg

price :

135 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2033736

products type :

Antibody

products full name :

Polyclonal Antibody to Liver X Receptor Beta (LXRb)

products short name :

Liver X Receptor Beta

products name syn :

NR1-H2; UNR; LXR-B; NER; NER-I; RIP15; Nuclear Receptor Subfamily 1,Group H,Member 2; Ubiquitously-Expressed Nuclear Receptor; Oxysterols receptor LXR-beta

other names :

liver X receptor beta; Oxysterols receptor LXR-beta; oxysterols receptor LXR-beta; nuclear receptor subfamily 1 group H member 2; Liver X receptor beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; Ubiquitously-expressed nuclear receptor

products gene name :

LXRb

other gene names :

NR1H2; NR1H2; NER; UNR; LXRB; LXR-b; NER-I; RIP15; LXRB; NER; UNR

uniprot entry name :

NR1H2_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Mouse

sequence length :

461

specificity :

The antibody is a rabbit polyclonal antibody raised against LXRb. It has been selected for its ability to recognize LXRb in immunohistochemical staining and western blotting.

purity :

Antigen-specific Affinity Chromatography.

form :

Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.

concentration :

200ug/ml

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 4 degree C for frequent use. Aliquot and store at -20 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed.The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.

app notes :

Western blotting: 0.5-2ug/ml. Immunocytochemistry in formalin fixed cells: 5-20ug/ml. Immunohistochemistry in formalin fixed frozen section: 5-20ug/ml. Immunohistochemistry in paraffin section: 5-20ug/ml. Enzyme-linked Immunosorbent Assay: 0.05-2ug/ml. Optimal working dilutions must be determined by end user.

other info1 :

Source: Polyclonal antibody preparation. Traits: Liquid

other info2 :

Immunogen: MBS2034266-Recombinant Liver X Receptor Beta (LXRb)

ncbi gi num :

216409702

ncbi acc num :

BAH02288.1

ncbi mol weight :

39,920 Da

ncbi pathways :

Gene Expression Pathway (1269649); Generic Transcription Pathway (1269650); Insulin Resistance Pathway (1272486); Nuclear Receptor Transcription Pathway (1269652); Nuclear Receptors Pathway (198848); SREBP Signalling Pathway (219802)

ncbi summary :

The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010]

uniprot summary :

LXR-beta: Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Forms a heterodimer with RXR. Ubiquitous. Belongs to the nuclear hormone receptor family. NR1 subfamily. Protein type: Nuclear receptor. Chromosomal Location of Human Ortholog: 19q13.3. Cellular Component: cytoplasm; nucleoplasm; nucleus. Molecular Function: apolipoprotein A-I receptor binding; ATPase binding; DNA binding; ligand-dependent nuclear receptor activity; protein binding; retinoid X receptor binding; steroid hormone receptor activity; zinc ion binding. Biological Process: cellular lipid metabolic process; cholesterol homeostasis; gene expression; negative regulation of lipid transport; negative regulation of pinocytosis; negative regulation of proteolysis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of cellular protein metabolic process; positive regulation of cholesterol transport; positive regulation of fatty acid biosynthetic process; positive regulation of lipoprotein lipase activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; retinoic acid receptor signaling pathway; steroid hormone mediated signaling; transcription initiation from RNA polymerase II promoter

size1 :

0.01 mg

price1 :

135 USD

size2 :

0.05 mg

price2 :

245

size3 :

0.1 mg

price3 :

325

more info or order :

MyBioSource product webpage