Diamine N-acetyltransferase 1, 1-171aa, Human, His-tag, Recombinant, E Coli | MyBioSource MBS203365 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Diamine N-acetyltransferase 1, 1-171aa, Human, His-tag, Recombinant, E Coli

catalog :

MBS203365

quantity :

0.1 mg

price :

375 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS203365

products type :

Recombinant Protein

products full name :

Diamine N-acetyltransferase 1, 1-171aa, Human, His-tag, Recombinant, E Coli

products short name :

Diamine N-acetyltransferase 1

products name syn :

spermidine/spermine N1-acetyltransferase 1; DC21; KFSD; KFSDX; SAT; SSAT; SSAT-1; SAT1; Diamine acetyltransferase 1; EC 2.3.1.57; Polyamine N-acetyltransferase 1; Putrescine acetyltransferase; Spermidine/spermine N(1)-acetyltransferase 1; SSAT 1.

other names :

diamine acetyltransferase 1; Diamine acetyltransferase 1; diamine acetyltransferase 1; diamine N-acetyltransferase 1; polyamine N-acetyltransferase 1; putrescine acetyltransferase; spermidine/spermine N1-acetyltransferase alpha; spermidine/spermine N1-acetyltransferase 1; Polyamine N-acetyltransferase 1; Putrescine acetyltransferase; Spermidine/spermine N(1)-acetyltransferase 1; SSAT; SSAT-1

other gene names :

SAT1; SAT1; SAT; DC21; KFSD; SSAT; KFSDX; SSAT-1; SAT; SSAT; SSAT-1

uniprot entry name :

SAT1_HUMAN

sequence length :

171

sequence :

MGSSHHHHHH SSGLVPRGSH MAKFVIRPAT AADCSDILRL IKELAKYEYM EEQVILTEKD LLEDGFGEHP FYHCLVAEVP KEHWTPEGHS IVGFAMYYFT YDPWIGKLLY LEDFFVMSDY RGFGIGSEIL KNLSQVAMRC RCSSMHFLVA EWNEPSINFY KRRGASDLSS EEGWRLFKID KEYLLKMATE E

purity :

> 95% by SDS - PAGE

form :

Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing, 10% glycerol

concentration :

1 mg/ml (determined by Bradford assay)

storage stability :

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

tested application :

SDS-PAGE

other info1 :

Antigen Species: Human. Tag: His-tag

other info2 :

Expression System: E Coli

products categories :

Enzymes & Proteases

products description :

Diamine N-acetyltransferase 1(or Spermidine/spermine-N1-acetyltransferase, SSAT1), as known as SAT-1, is a polyamine catabolic enzyme which catalyzes the acetylation of polyamines. This protein plays an important role in polyamine homoeostasis, since acetylated products are either excreted from the cell or oxidized by acetylpolyamine oxidase. A variety of other effects of increased SAT-1 activity include death of pancreatic cells, blockage of regenerative tissue growth, behavioral changes, keratosis follicularis spinulosa decalvans(KFSD), and hair loss. Recombinant human SAT-1, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.

products references :

Pegg AE., et al. (2008). Am J Physiol Endocrinol Metab. 294: E995-E1010,. Janne J., et al. (2006). J Cell Mol Med. 10(4):933-45.

ncbi gi num :

4506789

ncbi acc num :

NP_002961

ncbi gb acc num :

NM_002970.3

ncbi mol weight :

22.1 kDa (191aa), confirmed by MALDI-TOF.

ncbi pathways :

Arginine And Proline Metabolism Pathway (82957); Arginine And Proline Metabolism Pathway (323); GABA Biosynthesis, Eukaryotes, Putrescine = GABA Pathway (413399); GABA Biosynthesis, Eukaryotes, Putrescine = GABA Pathway (468314); Interconversion Of Polyamines Pathway (106195); Metabolic Pathways (132956); Metabolism Pathway (477135); Metabolism Of Amino Acids And Derivatives Pathway (106169); Metabolism Of Polyamines Pathway (106193); Nucleotide Metabolism Pathway (198876)

ncbi summary :

The protein encoded by this gene belongs to the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Defects in this gene are associated with keratosis follicularis spinulosa decalvans (KFSD). Alternatively spliced transcripts have been found for this gene.[provided by RefSeq, Sep 2009]

uniprot summary :

SAT: Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine spermine N(1)-acetylspermine putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine. Defects in SAT1 may be a cause of keratosis follicularis spinulosa decalvans X-linked (KFSDX). A rare disorder affecting the skin and the eye. Affected men show thickening of the skin of the neck, ears, and extremities, especially the palms and soles, loss of eyebrows, eyelashes and beard, thickening of the eyelids with blepharitis and ectropion, and corneal degeneration. Belongs to the acetyltransferase family. Protein type: EC 2.3.1.57; Acetyltransferase; Amino Acid Metabolism - arginine and proline. Chromosomal Location of Human Ortholog: Xp22.1. Cellular Component: intracellular; cytosol. Molecular Function: protein binding; diamine N-acetyltransferase activity; spermidine binding. Biological Process: spermidine acetylation; polyamine biosynthetic process; putrescine catabolic process; angiogenesis; regulation of cell proliferation; polyamine metabolic process. Disease: Keratosis Follicularis Spinulosa Decalvans, X-linked

size1 :

0.1 mg

price1 :

375 USD

size2 :

0.5 mg

price2 :

925

more info or order :

MyBioSource product webpage