protein

Neurokinin B, 17-121aa, Human, His-tag, Recombinant, E Coli

MBS203363

0.1 mg

310 USD

Recombinant Protein

Neurokinin B, 17-121aa, Human, His-tag, Recombinant, E Coli

Neurokinin B

ZNEuROK1; Neuromedin K; Tachykinin3; TAC3; NKB; NKNB; Gamma tachykinin 3; Neurokinin B like protein; Neurokinin B protein; Neurokinin beta; NeurokininB; NeuromedinK; Preprotachykinin B; PreprotachykininB; PRO 1155; PRO1155; TAC 3; Tachykinin 3; Tachykinin3; ZNEuROK 1.

tachykinin-3 isoform 1 preproprotein; Tachykinin-3; tachykinin-3; gamma tachykinin 3; neurokinin b; neuromedin K; preprotachykinin B; preprotachykinin-B; tachykinin 3; ZNEUROK1Neurokinin-B; NKBAlternative name(s):Neuromedin-K

TAC3; TAC3; NKB; HH10; NKNB; PRO1155; ZNEUROK1; NKNB; NKB

TKNK_HUMAN

121

MGSSHHHHHH SSGLVPRGSH QSFGAVCKEP QEEVVPGGGR SKRDPDLYQL LQRLFKSHSS LEGLLKALSQ ASTDPKESTS PEKRDMHDFF VGLMGKRSVQ PDSPTDVNQE NVPSFGILKY PPRAE

> 95% by SDS - PAGE

Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol

0.5 mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human. Tag: His-tag

Expression System: E Coli

Neuroscience

Neurokinin B, a member of the substance P-related tachykinin family, was previously known to be present in the same hypothalamic neurons as kisspeptin. This protein and its receptor are critical switches of regulator of human puberty, governed by the brain through the release of the hormone GnRH (gonadotropin-releasing hormone) which starts a series of processes that ultimately leads to the production of sex hormones. Many studies suggest new approaches to the pharmacological control of human reproduction and sex hormone-related diseases. Recombinant human Neurokinin B, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.

Topaloglu AK., et al. (2009). Nat Genet. 41(3):354-8. Rance NE., et al. (2009). Peptides. 30(1):111-22.

7019577

NP_037383

NM_013251.3

13.8 kDa (125aa), confirmed by MALDI-TOF.

Class A/1 (Rhodopsin-like Receptors) Pathway 106357!!Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway 1127664!!Disease Pathway 530764!!G Alpha (q) Signalling Events Pathway 106043!!GPCR Downstream Signaling Pathway 119548!!GPCR Ligand Binding Pathway 161020!!Gastrin-CREB Signalling Pathway Via PKC And MAPK 645295!!Metabolic Disorders Of Biological Oxidation Enzymes Pathway 1127637!!Peptide Ligand-binding Receptors Pathway 106358!!Signal Transduction Pathway 477114

This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded protein is primarily expressed in the central and peripheral nervous system and functions as a neurotransmitter. This protein is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

0.1 mg

310 USD