protein

Recombinant Pro-Gastrin Releasing Peptide (ProGRP)

MBS2033543

0.01 mg

135 USD

Recombinant Protein

Recombinant Pro-Gastrin Releasing Peptide (ProGRP)

[Pro-Gastrin Releasing Peptide]

[pro-GRP; preproGRP; pre-proGRP]

[pro-gastrin releasing peptide type 2, partial; Gastrin-releasing peptide; gastrin-releasing peptide; gastrin releasing peptide; Neuromedin-CAlternative name(s):GRP-10]

[ProGRP]

[GRP; GRP; BN; GRP-10; proGRP; preproGRP; GRP]

GRP_HUMAN

E.coli

>90%

20mM Tris, 150mM NaCl, pH8.0, containing 0.01% SKL, 5% Trehalose.

Original Concentration: 200 ug/mL

Storage: Avoid repeated freeze/thaw cycles. Store at 2-8ºC for one month. Aliquot and store at -80ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Positive Control; Immunogen; SDS-PAGE; Western Blot (WB). (May be suitable for use in other assays to be determined by the end user.)

Sequence Information

SDS-Page

Testing Data

Organism Species: Homo sapiens (Human). Source: Prokaryotic expression. Residues: Ser54~Gln148. Tags: N-terminal His Tag. Subcellular Location: Secreted. Traits: Freeze-dried powder. Predicted isoelectric point: 9.2. Predicted Molecular Mass: 14.0kDa. Accurate Molecular Mass: 16kDa as determined by SDS-PAGE reducing conditions. Usage: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

386757

AAA52612.1

Class A/1 (Rhodopsin-like Receptors) Pathway (1269545); G Alpha (q) Signalling Events Pathway (1269578); GPCR Downstream Signaling Pathway (1269574); GPCR Ligand Binding Pathway (1269544); Gastrin-CREB Signalling Pathway Via PKC And MAPK (1269592); Incretin Synthesis, Secretion, And Inactivation Pathway (1268750); Metabolism Of Proteins Pathway (1268677); Peptide Hormone Metabolism Pathway (1268746); Peptide Ligand-binding Receptors Pathway (1269546); Signal Transduction Pathway (1269379)

This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. The encoded preproprotein is proteolytically processed to generate two peptides, gastrin-releasing peptide and neuromedin-C. These peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

GRP: GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP- receptor gene expression, long-term potentiation, and amygdala- dependent memory for fear. Belongs to the bombesin/neuromedin-B/ranatensin family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 18q21.1-q21.32. Cellular Component: extracellular region; extracellular space. Molecular Function: neuropeptide hormone activity; receptor binding. Biological Process: neuropeptide signaling pathway; signal transduction

0.01 mg

135 USD

0.05 mg

245

0.1 mg

370

0.2 mg

455

0.5 mg

880

1 mg

1300