product summary
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company name :
MyBioSource
product type :
protein
product name :
Interleukin 6, 30-212aa, Human, His-tag, Recombinant, E Coli
catalog :
MBS203353
quantity :
0.1 mg
price :
375 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS203353
products type :
Recombinant Protein
products full name :
Interleukin 6, 30-212aa, Human, His-tag, Recombinant, E Coli
products short name :
Interleukin 6
products name syn :
HGF; HSF; BSF2; IL-6; IFNB2; IL6; interleukin 6 (interferon; beta 2)
other names :
interleukin-6; Interleukin-6; interleukin-6; B-cell differentiation factor; B-cell stimulatory factor 2; BSF-2; CDF; CTL differentiation factor; IFN-beta-2; hybridoma growth factor; interferon beta-2; interferon, beta 2; interleukin BSF-2; interleukin 6; B-cell stimulatory factor 2; BSF-2; CTL differentiation factor; CDF; Hybridoma growth factor; Interferon beta-2; IFN-beta-2
other gene names :
IL6; IL6; HGF; HSF; BSF2; IL-6; IFNB2; IFNB2; IL-6; BSF-2; CDF; IFN-beta-2
uniprot entry name :
IL6_HUMAN
sequence length :
212
sequence :
MGSSHHHHHH SSGLVPRGSH MVPPGEDSKD VAAPHRQPLT SSERIDKQIR YILDGISALR KETCNKSNMC ESSKEALAEN NLNLPKMAEK DGCFQSGFNE ETCLVKIITG LLEFEVYLEY LQNRFESSEE QARAVQMSTK VLIQFLQKKA KNLDAITTPD PTTNASLLTK LQAQNQWLQD MTTHLILRSF KEFLQSSLRA LRQM
purity :
> 95% by SDS - PAGE
form :
Liquid. In Phosphate Buffered Saline (pH7.4) containing 10% glycerol
concentration :
0.5 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human. Tag: His-tag
other info2 :
Expression System: E Coli. Endotoxin: < 1.0 Eu per 1 microgram of protein (determined by LAL method)
products categories :
Hormones & Cytokines
products description :
Interleukin-6, as known as IL-6, is an immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. It is also a 'myokine,' a cytokine produced from muscle, and is elevated in response to muscle contraction. IL-6 acts as both a pro-inflammatory and anti-inflammatory cytokine. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6. It is mediated through its inhibitory effects on TNF-alpha and IL-1, and activation of IL-1ra and IL-10. Recombinant interleukin-6 was expressed in E.coli and purifed by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.
products references :
Ishihara, et al. (2002) Cytokine Growth Factor Rev. 13(4-5):357-68. Vgontzas AN, et al. (2005) Neuroimmunomodulation.12, 131-40.
ncbi gi num :
10834984
ncbi acc num :
NP_000591
ncbi gb acc num :
NM_000600.3
ncbi mol weight :
23.1 kDa (204 aa), confirmed by MALDI-TOF.
ncbi pathways :
ARMS-mediated Activation Pathway 106466!!ATF-2 Transcription Factor Network Pathway 138006!!Activated TLR4 Signalling Pathway 106400!!Adipogenesis Pathway 198832!!African Trypanosomiasis Pathway 194384!!African Trypanosomiasis Pathway 194323!!Amoebiasis Pathway 167324!!Amoebiasis Pathway 167191!!Axon Guidance Pathway 105688!!Cellular Senescence Pathway 905991
ncbi summary :
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. [provided by RefSeq, Jun 2011]
size :
0.1 mg
price :
375 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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