Recombinant Carbonyl Reductase 1 (CBR1) | MyBioSource MBS2033511 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Carbonyl Reductase 1 (CBR1)

catalog :

MBS2033511

quantity :

0.01 mg

price :

130 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS2033511

products type :

Recombinant Protein

products full name :

Recombinant Carbonyl Reductase 1 (CBR1)

products short name :

[Carbonyl Reductase 1]

products name syn :

[CBR; SDR21C1; CRN; Short Chain Dehydrogenase/Reductase Family 21C,Member 1; 15-hydroxyprostaglandin dehydrogenase [NADP(+)]; Prostaglandin 9-ketoreductase]

other names :

[carbonyl reductase 1; Carbonyl reductase [NADPH] 1; carbonyl reductase [NADPH] 1; carbonyl reductase 1; 15-hydroxyprostaglandin dehydrogenase [NADP(+)] (EC:1.1.1.197); NADPH-dependent carbonyl reductase 1; Prostaglandin 9-ketoreductase; Prostaglandin-E(2) 9-reductase (EC:1.1.1.189); Short chain dehydrogenase/reductase family 21C member 1]

products gene name :

[CBR1]

other gene names :

[CBR1; CBR1; CBR; hCBR1; SDR21C1; CBR; CRN; SDR21C1]

uniprot entry name :

CBR1_HUMAN

host :

E Coli

purity :

> 97%

form :

20mM Tris, 150mM NaCl, pH8.0, containing 5% Trehalose.

concentration :

Original Concentration: 800 ug/mL

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 2-8ºC for one month. Aliquot and store at -80ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

Positive Control; Immunogen; SDS-PAGE; WB. (May be suitable for use in other assays to be determined by the end user.)

image1 heading :

SDS-Page

other info1 :

Organism Species: Homo sapiens (Human). Source: Prokaryotic expression. Tags: N-terminal His Tag. Subcellular Location: Cytoplasm. Traits: Freeze-dried powder. Residues: Ser2~Trp277

other info2 :

Predicted isoelectric point: 8.6. Predicted Molecular Mass: 37.6kDa. Accurate Molecular Mass: 35kDa as determined by SDS-PAGE reducing conditions. Usage: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

ncbi gi num :

6693616

ncbi acc num :

BAA89424.1

ncbi pathways :

Arachidonic Acid Metabolism Pathway (82991); Arachidonic Acid Metabolism Pathway (1270087); Arachidonic Acid Metabolism Pathway (366); Chemical Carcinogenesis Pathway (673221); Chemical Carcinogenesis Pathway (673237); Metabolic Pathways (132956); Metabolism Pathway (1269956); Metabolism Of Lipids And Lipoproteins Pathway (1270001); Metabolism Of Xenobiotics By Cytochrome P450 Pathway (83031); Metabolism Of Xenobiotics By Cytochrome P450 Pathway (425)

ncbi summary :

The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]

uniprot summary :

CBR1: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. Belongs to the short-chain dehydrogenases/reductases (SDR) family. Protein type: EC 1.1.1.197; EC 1.1.1.189; EC 1.1.1.184; Lipid Metabolism - arachidonic acid; Oxidoreductase. Chromosomal Location of Human Ortholog: 21q22.13. Cellular Component: cytosol. Molecular Function: 15-hydroxyprostaglandin dehydrogenase (NADP+) activity; carbonyl reductase (NADPH) activity; oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor; prostaglandin-E2 9-reductase activity. Biological Process: arachidonic acid metabolic process; cyclooxygenase pathway; drug metabolic process; epithelial cell differentiation; vitamin K metabolic process

size1 :

0.01 mg

price1 :

130 USD

size2 :

0.05 mg

price2 :

225

size3 :

0.1 mg

price3 :

340

size4 :

0.2 mg

price4 :

415

size5 :

0.5 mg

price5 :

800

size6 :

1 mg

price6 :

1180

more info or order :

MyBioSource product webpage