product summary
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company name :
MyBioSource
product type :
protein
product name :
Carbonyl reductase 3, 1-277aa, Human, His-tag, Recombinant, E Coli
catalog :
MBS203346
quantity :
0.1 mg
price :
310 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS203346
products type :
Recombinant Protein
products full name :
Carbonyl reductase 3, 1-277aa, Human, His-tag, Recombinant, E Coli
products short name :
Carbonyl reductase 3
products name syn :
Carbonyl reductase 3; CBR3; NADPH-dependent carbonyl reductase; Carbonyl reductase (NADPH) 3; EC 1.1.1.184; hCBR3; Carbonyl reductase (NADPH) 3 EC 1.1.1.184; NADPH dependent carbonyl reductase 3; SDR21C2; Short chain dehydrogenase/reductase family 21C member 2.
other names :
carbonyl reductase; Carbonyl reductase [NADPH] 3; carbonyl reductase [NADPH] 3; carbonyl reductase [NADPH] 3; NADPH-dependent carbonyl reductase 3; carbonyl reductase (NADPH) 3; epididymis secretory protein Li 25; short chain dehydrogenase/reductase family 21C, member 2; carbonyl reductase 3; NADPH-dependent carbonyl reductase 3
other gene names :
CBR3; CBR3; hCBR3; SDR21C2; HEL-S-25
uniprot entry name :
CBR3_HUMAN
sequence length :
277
sequence :
MGSSHHHHHH SSGLVPRGSH MSSCSRVALV TGANRGIGLA IARELCRQFS GDVVLTARDV ARGQAAVQQL QAEGLSPRFH QLDIDDLQSI RALRDFLRKE YGGLNVLVNN AAVAFKSDDP MPFDIKAEMT LKTNFFATRN MCNELLPIMK PHGRVVNISS LQCLRAFENC SEDLQERFHS ETLTEGDLVD LMKKFVEDTK NEVHEREGWP NSPYGVSKLG VTVLSRILAR RLDEKRKADR ILVNACCPGP VKTDMDGKDS IRTVEEGAET PVYLALLPPD ATEPQGQLVH DKVVQNW
purity :
> 95% by SDS - PAGE
form :
Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol.
concentration :
1 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human. Tag: His-tag
other info2 :
Expression System: E Coli
products categories :
Redox Proteins
products description :
Carbonyl reductase 3(CBR3) is one of several monomeric NADPH-dependent oxidoreductases. This protein catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. It also contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1. Some studies suggest that it mediates 9-cis-retinoic acid-induced cytostatis and is a potential prognostic marker for oral malignancy. Recombinant human CBR3, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
products references :
Ohkura-Hada S., et al. (2008). Open Dent J. 2:78-88. Miura T., et al. (2009). Life Sci. 85(7-8):303-8.
ncbi gi num :
4502601
ncbi acc num :
NP_001227
ncbi gb acc num :
NM_001236.3
ncbi mol weight :
33 kDa (297aa), confirmed by MALDI-TOF.
ncbi pathways :
Arachidonic Acid Metabolism Pathway (82991); Arachidonic Acid Metabolism Pathway (366); Metabolic Pathways (132956); Metabolism Of Xenobiotics By Cytochrome P450 Pathway (83031); Metabolism Of Xenobiotics By Cytochrome P450 Pathway (425)
ncbi summary :
Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1. [provided by RefSeq, Jul 2008]
uniprot summary :
CBR3: Has low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro). Belongs to the short-chain dehydrogenases/reductases (SDR) family. Protein type: EC 1.1.1.184; Lipid Metabolism - arachidonic acid; Oxidoreductase. Chromosomal Location of Human Ortholog: 21q22.2. Cellular Component: nucleoplasm; extracellular space; cytoplasm; cytosol. Molecular Function: 3-keto sterol reductase activity; carbonyl reductase (NADPH) activity. Biological Process: phylloquinone catabolic process; cognition
size1 :
0.1 mg
price1 :
310 USD
size2 :
0.5 mg
price2 :
720
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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