product summary
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company name :
MyBioSource
product type :
protein
product name :
Maspin, 1-375aa, Human, His-tag, Recombinant, E Coli
catalog :
MBS203332
quantity :
0.1 mg
price :
310 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS203332
products type :
Recombinant Protein
products full name :
Maspin, 1-375aa, Human, His-tag, Recombinant, E Coli
products short name :
Maspin
products name syn :
Serine (or cysteine) proteinase inhibitor clade B (ovalbumin) member 5; Serpin B5; Protease inhibitor 5; SERPINB5; PI5; Serine (or cysteine) proteinase inhibitor clade B (ovalbumin) member 5 Serine (or cysteine) peptidase inhibitor; clade B; member 5; Ovalbumin; PI-5; Serpin peptidase inhibitor; Serpin peptidase inhibitor; clade B (ovalbumin); member 5; SERPINB5; Spi5; Spi7.
other names :
serpin B5; Serpin B5; serpin B5; PI-5; peptidase inhibitor 5; protease inhibitor 5 (maspin); serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5; serpin peptidase inhibitor, clade B (ovalbumin), member 5; Maspin; Peptidase inhibitor 5; PI-5
other gene names :
SERPINB5; SERPINB5; PI5; maspin; PI5; PI-5
uniprot entry name :
SPB5_HUMAN
sequence length :
375
sequence :
MGSSHHHHHH SSGLVPRGSH MDALQLANSA FAVDLFKQLC EKEPLGNVLF SPICLSTSLS LAQVGAKGDT ANEIGQVLHF ENVKDVPFGF QTVTSDVNKL SSFYSLKLIK RLYVDKSLNL STEFISSTKR PYAKELETVD FKDKLEETKG QINNSIKDLT DGHFENILAD NSVNDQTKIL VVNAAYFVGK WMKKFPESET KECPFRVNKT DTKPVQMMNM EATFCMGNID SINCKIMELP FQNKHLSMFI LLPKDVEDES TGLEKIEKQL NSESLSQWTN PSTMANAKVK LSIPKFKVEK MIDPKACLEN LGLKHIFSED TSDFSGMSET KGVALSNVIH KVCLEITEDG GDSIEVPGAR ILQHKDELNA DHPFIYIIRH NKTRNIIFFG KFCSP
purity :
> 95% by SDS - PAGE
form :
Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol.
concentration :
1 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human. Tag: His-tag
other info2 :
Expression System: E Coli. Endotoxin: < 1.0 Eu per 1 microgram of protein (determined by LAL method)
products categories :
Proteases & Inhibitors
products description :
Serine (or cysteine) proteinase inhibitor clade B (ovalbumin) member 5, also known as Maspin, is a tumor suppressor protein of serine proteinase inhibitor family. It plays an essential role in embryonic development through critical roles in cell adhesion. Also, it is present in normal breast and prostatic epithelial cells but downregulated in the respective carcinomas. Recombinant human Maspin, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
products references :
Lockett J., et al. (2006). J Cell Biochem. 97(4):651-60. Khalkhali Ellis Z., et al. (2006). Clin Cancer Res. 12(24):7279-83.
ncbi gi num :
167860126
ncbi acc num :
NP_002630
ncbi gb acc num :
NM_002639.4
ncbi mol weight :
44.2 kDa (395aa), confirmed by MALDI-TOF.
ncbi pathways :
ATF-2 Transcription Factor Network Pathway (138006); Direct P53 Effectors Pathway (137939); MicroRNAs In Cancer Pathway (852705); MicroRNAs In Cancer Pathway (852928); P53 Signaling Pathway (83055); P53 Signaling Pathway (465)
uniprot summary :
maspin: Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. Interacts with IRF6. Normal mammary epithelial cells. Belongs to the serpin family. Ov-serpin subfamily. 2 isoforms of the human protein are produced by alternative splicing. Chromosomal Location of Human Ortholog: 18q21.33. Cellular Component: extracellular space; cytoplasm. Molecular Function: serine-type endopeptidase inhibitor activity; protein binding. Biological Process: extracellular matrix organization and biogenesis; morphogenesis of an epithelium; cell motility; regulation of epithelial cell proliferation
size1 :
0.1 mg
price1 :
310 USD
size2 :
0.5 mg
price2 :
720
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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