product summary
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company name :
MyBioSource
product type :
protein
product name :
WWOX, 1-234aa, Human, His-tag, Recombinant, E Coli
catalog :
MBS203331
quantity :
0.05 mg
price :
310 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS203331
products type :
Recombinant Protein
products full name :
WWOX, 1-234aa, Human, His-tag, Recombinant, E Coli
products short name :
WWOX
products name syn :
WW domain containing oxidoreductase; D16S432E; FOR; FRA16D; HHCMA56; PRO0128; SDR41C1; WOX1; WW domain containing oxidoreductase 5330426P09Rik; 9030416C10Rik; EC 1.1.1.- Fragile site FRA16D Oxireductase; MGC55975; PRO0128; Putative oxidoreductase; zgc:55975; Short chain dehydrogenase/reductase family 41C; member 1; WW domain-containing protein WWOX.
other names :
WWOX protein; WW domain-containing oxidoreductase; WW domain-containing oxidoreductase; WW domain-containing protein WWOX; fragile site FRA16D oxidoreductase; short chain dehydrogenase/reductase family 41C, member 1; WW domain containing oxidoreductase; Fragile site FRA16D oxidoreductase
products gene name :
WWOX
other gene names :
WWOX; WWOX; FOR; WOX1; FRA16D; SCAR12; HHCMA56; PRO0128; SDR41C1; D16S432E; FOR; WOX1
uniprot entry name :
WWOX_HUMAN
sequence length :
234
sequence :
MGSSHHHHHH SSGLVPRGSH MAALRYAGLD DTDSEDELPP GWEERTTKDG WVYYANHTEE KTQWEHPKTG KRKRVAGDLP YGWEQETDEN GQVFFVDHIN KRTTYLDPRL AFTVDDNPTK PTTRQRYDGS TTAMEILQGR DFTGKVVVVT GANSGIGFET AKSFALHGAH VILACRNMAR ASEAVSRILE EWQQGAATTV YCAAVPELEG LGGMYFNNCC RCMPSPEAQS EETARTLWAL SERLIQERLG SQSG
purity :
> 85% by SDS - PAGE
form :
Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
concentration :
1 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human. Tag: His-tag
other info2 :
Expression System: E Coli
products categories :
Redox Proteins
products description :
WWOX, also known as WW domain containing oxidoreductase, is a proapoptotic protein and a tumor suppressor protein. WWOX is found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This protein may function synergistically with TP53/p53 to control genotoxic stress-induced cell death. It also plays a role in tumor necrosis factor (TNF)-mediated cell death. Recombinant human WWOX protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
products references :
Bouteille N., et al. (2009), Oncogene. 28(28):2569-80. Gourley C., et al. (2009). Cancer Res. 69(11):4835-42.
ncbi gi num :
13112021
ncbi acc num :
AAH03184
ncbi mol weight :
28.3 kDa (254aa), confirmed by MALDI-TOF.
ncbi pathways :
ErbB4 Signaling Events Pathway 137991!!Nuclear Signaling By ERBB4 Pathway 530744!!Signal Transduction Pathway 477114!!Signaling By ERBB4 Pathway 530741
ncbi summary :
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
size :
0.05 mg
price :
310 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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