catalog number :
MBS203329
products type :
Recombinant Protein
products full name :
NDuFS4, 43-175aa, Human, Recombinant, E Coli
products short name :
NDuFS4
products name syn :
NADH dehydrogenase (ubiquinone) Fe-S protein 4; AQDQ; NADH dehydrogenase (ubiquinone) Fe-S protein 4 CI 18 kDa; CI AQDQ; Complex I 18 kDa; Complex I AQDQ; mitochondrial respiratory chain complex I (18 KD subunit); NADH dehydrogenase; NADH ubiquinone oxidoreductase 18 kDa subunit.
other names :
NADH dehydrogenase; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial; CI-18 kDa; CI-AQDQ; NADH dehydrogenase (ubiquinone) iron-sulfur protein 4; NADH-coenzyme Q reductase, 18-KD; NADH-ubiquinone oxidoreductase 18 kDa subunit; complex I 18kDa subunit; complex I-18 kDa; complex I-AQDQ; mitochondrial respiratory chain complex I (18-KD subunit); NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase); Complex I-18 kDa; CI-18 kDa; Complex I-AQDQ; CI-AQDQ; NADH-ubiquinone oxidoreductase 18 kDa subunit
products gene name :
NDuFS4
other gene names :
NDUFS4; NDUFS4; AQDQ; CI-18; CI-18 kDa; CI-AQDQ
uniprot entry name :
NDUS4_HUMAN
sequence :
MAQDQTQDTQ LITVDEKLDI TTLTGVPEEH IKTRKVRIFV PARNNMQSGV NNTKKWKMEF DTRERWENPL MGWASTADPL SNMVLTFSTK EDAVSFAEKN GWSYDIEERK VPKPKSKSYG ANFSWNKRTR VSTK
purity :
> 90% by SDS - PAGE
form :
Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 30% glycerol
concentration :
0.5 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human
other info2 :
Expression System: E Coli
products categories :
Metabolism
products description :
NDuFS4, also known as NADH dehydrogenase (ubiquinone) Fe-S protein 4, is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), the first multi-subunit enzyme complex of the mitochondrial respiratory chain. Complex I plays a vital role in cellular ATP production, the primary source of energy for many crucial processes in living cells. It removes electrons from NADH and passes them by a series of different protein-coupled redox centers to the electron acceptor ubiquinone. Recombinant human NDuFS4 protein was expressed in E.coli and purified by using conventional chromatography.
products references :
Choi WS., et al. (2008), Proc Natl Acad Sci u S A. 105(39):15136-41. De Rasmo D., et al. (2008). Cell Signal. 20(5):989-97.
ncbi gb acc num :
NM_002495.2
ncbi mol weight :
15.5 kDa (134aa), confirmed by MALDI-TOF.
ncbi pathways :
Alzheimer's Disease Pathway 83097!!Alzheimer's Disease Pathway 509!!Electron Transport Chain Pathway 198860!!Huntington's Disease Pathway 83100!!Huntington's Disease Pathway 512!!Metabolic Pathways 132956!!Metabolism Pathway 477135!!NADH Dehydrogenase (ubiquinone) Fe-S Protein/flavoprotein Complex, Mitochondria Pathway 413407!!NADH Dehydrogenase (ubiquinone) Fe-S Protein/flavoprotein Complex, Mitochondria Pathway 890441!!Non-alcoholic Fatty Liver Disease (NAFLD) Pathway 862188
ncbi summary :
This gene encodes an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), or NADH:ubiquinone oxidoreductase, the first multi-subunit enzyme complex of the mitochondrial respiratory chain. Complex I plays a vital role in cellular ATP production, the primary source of energy for many crucial processes in living cells. It removes electrons from NADH and passes them by a series of different protein-coupled redox centers to the electron acceptor ubiquinone. In well-coupled mitochondria, the electron flux leads to ATP generation via the building of a proton gradient across the inner membrane. Complex I is composed of at least 41 subunits, of which 7 are encoded by the mitochondrial genome and the remainder by nuclear genes. [provided by RefSeq, Jul 2008]