Recombinant Small Heterodimer Partner (SHP) | MyBioSource MBS2033279 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Small Heterodimer Partner (SHP)

catalog :

MBS2033279

quantity :

0.01 mg

price :

140 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS2033279

products type :

Recombinant Protein

products full name :

Recombinant Small Heterodimer Partner (SHP)

products short name :

[Small Heterodimer Partner]

products name syn :

[NR0B2; SHP1; Nuclear Receptor Subfamily 0,Group B,Member 2; Orphan nuclear receptor SHP]

other names :

[small heterodimer partner; Nuclear receptor subfamily 0 group B member 2; nuclear receptor subfamily 0 group B member 2; nuclear receptor subfamily 0 group B member 2; Orphan nuclear receptor SHP; Small heterodimer partner]

products gene name :

[SHP]

other gene names :

[NR0B2; NR0B2; SHP; SHP1; SHP]

uniprot entry name :

NR0B2_HUMAN

host :

E Coli

purity :

>90%

concentration :

Original Concentration: 300 ug/mL

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 2-8ºC for one month. Aliquot and store at -80ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

Positive Control; Immunogen; SDS-PAGE; Western Blot (WB). (May be suitable for use in other assays to be determined by the end user.)

image1 heading :

SDS-Page

other info1 :

Organism Species: Homo sapiens (Human). Source: Prokaryotic expression. Residues: Met1~Arg257. Tags: N-terminal His Tag. Subcellular Location: Nucleus, Cytoplasm. Traits: Freeze-dried powder. Buffer: 100mMNaHCO3, 500mMNaCl, pH8.3, containing 0.01% SKL, 5% Trehalose.

other info2 :

Predicted isoelectric point: 8.3. Predicted Molecular Mass: 31.8kDa. Accurate Molecular Mass: 32kDa as determined by SDS-PAGE reducing conditions. Usage: Reconstitute in 100mM NaHCO3, 500mM NaCl (pH8.3) to a concentration of 0.1-1.0 mg/mL. Do not vortex

ncbi gi num :

15787843

ncbi acc num :

BAB68530.1

ncbi pathways :

Androgen Receptor Signaling Pathway (198806); Bile Secretion Pathway (193146); Bile Secretion Pathway (193095); Gene Expression Pathway (1269649); Generic Transcription Pathway (1269650); Nuclear Receptor Transcription Pathway (1269652)

ncbi summary :

The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008]

uniprot summary :

NR0B2: Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box- containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1. Defects in NR0B2 may be associated with obesity (OBESITY). It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Belongs to the nuclear hormone receptor family. NR0 subfamily. Protein type: Nuclear receptor; Transcription, coactivator/corepressor; Nuclear receptor co-regulator. Chromosomal Location of Human Ortholog: 1p36.1. Cellular Component: cytoplasm; nucleoplasm; nucleus; protein complex. Molecular Function: DNA binding; peroxisome proliferator activated receptor binding; protein binding; protein complex binding; protein domain specific binding; protein homodimerization activity; retinoid X receptor binding; steroid hormone receptor activity; thyroid hormone receptor binding; transcription corepressor activity; transcription factor binding. Biological Process: cholesterol metabolic process; gene expression; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; Notch signaling pathway; organ regeneration; positive regulation of insulin secretion; response to glucose stimulus; steroid hormone mediated signaling; transcription initiation from RNA polymerase II promoter. Disease: Obesity

size1 :

0.01 mg

price1 :

140 USD

size2 :

0.05 mg

price2 :

260

size3 :

0.1 mg

price3 :

400

size4 :

0.2 mg

price4 :

495

size5 :

0.5 mg

price5 :

955

size6 :

1 mg

price6 :

1415

more info or order :

MyBioSource product webpage