protein

Chromogranin-A, 19-457aa, Human, His-tag, Recombinant, E Coli

MBS203324

0.05 mg

375 USD

Recombinant Protein

Chromogranin-A, 19-457aa, Human, His-tag, Recombinant, E Coli

Chromogranin-A

CgA; CHGA; Pituitary secretory protein I (SP1); Chromogranin-A; beta Granin; CHG A; Chromogranin A precursor; SP I; Chromogranin A parathyroid secretory protein 1; ChromograninA; Pancreastatin; Parastatin; Parathyroid secretory protein 1; SP1; SPI; Vasostatin; Pituitary secretory protein I

chromogranin-A isoform 1 preproprotein; Chromogranin-A; chromogranin-A; SP-I; betagranin (N-terminal fragment of chromogranin A); catestatin; chromofungin; parathyroid secretory protein 1; pituitary secretory protein I; chromogranin A (parathyroid secretory protein 1); Pituitary secretory protein I; SP-I

CHGA; CHGA; CGA; CgA; SP-I

CMGA_HUMAN

457

MGSSHHHHHH SSGLVPRGSH MLPVNSPMNK GDTEVMKCIV EVISDTLSKP SPMPVSQECF ETLRGDERIL SILRHQNLLK ELQDLALQGA KERAHQQKKH SGFEDELSEV LENQSSQAEL KEAVEEPSSK DVMEKREDSK EAEKSGEATD GARPQALPEP MQESKAEGNN QAPGEEEEEE EEATNTHPPA SLPSQKYPGP QAEGDSEGLS QGLVDREKGL SAEPGWQAKR EEEEEEEEEA EAGEEAVPEE EGPTVVLNPH PSLGYKEIRK GESRSEALAV DGAGKPGAEE AQDPEGKGEQ EHSQQKEEEE EMAVVPQGLF RGGKSGELEQ EEERLSKEWE DSKRWSKMDQ LAKELTAEKR LEGQEEEEDN RDSSMKLSFR ARAYGFRGPG PQLRRGWRPS SREDSLEAGL PLQVRGYPEE KKEEEGSANR RPEDQELESL SAIEAELEKV AHQLQALRRG

> 85% by SDS - PAGE

20mM Tris-HCl (ph.7.5) containing 2mM EDTA, 0.1mM PMSF, 10% Glycerol

0.5 mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human. Tag: His-tag

Expression System: E Coli

Cancer

Chromogranin A is a member of the chromogranin/secretogranin (granins) family of neuroendocrine secretory proteins. Chromogranin A (CgA) represents the major soluble protein co-stored and co-released with catecholamines, within chromaffin cells secretory granules. Chromogranin A is the precursor to several functional peptides including vasostatin, pancreastatin, catestatin and parastatin. It is considered a diagnostic and prognostic marker of several diseases, including a variety of tumours and cardiac heart failure. Recombinant human Chromogranin A, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.

Montero-Hadjadje M., et al. (2009). J Biol Chem. 284(18):12420-31. Hendy GN., et al. (1995). Clin Invest Med. 18(1):47-65.

4502805

NP_001266

NM_001275.3

51.2 kDa (460aa) (Molecular weight on SDS-PAGE will appear higher)

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

0.05 mg

375 USD