product summary
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company name :
MyBioSource
product type :
protein
product name :
NNMT, 1-264aa, Human, His-tag, Recombinant, E Coli
catalog :
MBS203321
quantity :
0.1 mg
price :
310 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS203321
products type :
Recombinant Protein
products full name :
NNMT, 1-264aa, Human, His-tag, Recombinant, E Coli
products short name :
NNMT
products name syn :
Nicotinamide N-methyltransferase; NNMT; Nicotinamide N-methyltransferase EC 2.1.1.1 Nicotinamide N methyltransferase.
other names :
nicotinamide N-methyltransferase; Nicotinamide N-methyltransferase; nicotinamide N-methyltransferase; nicotinamide N-methyltransferase
products gene name :
NNMT
other gene names :
NNMT; NNMT
uniprot entry name :
NNMT_HUMAN
sequence length :
264
sequence :
MGSSHHHHHH SSGLVPRGSH MESGFTSKDT YLSHFNPRDY LEKYYKFGSR HSAESQILKH LLKNLFKIFC LDGVKGDLLI DIGSGPTIYQ LLSACESFKE IVVTDYSDQN LQELEKWLKK EPEAFDWSPV VTYVCDLEGN RVKGPEKEEK LRQAVKQVLK CDVTQSQPLG AVPLPPADCV LSTLCLDAAC PDLPTYCRAL RNLGSLLKPG GFLVIMDALK SSYYMIGEQK FSSLPLGREA VEAAVKEAGY TIEWFEVISQ SYSSTMANNE GLFSLVARKL SRPL
purity :
> 95% by SDS - PAGE
form :
Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol
concentration :
1 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human. Tag: His-tag
other info2 :
Expression System: E Coli
products categories :
Enzymes & Proteases
products description :
NNMT(Nicotinamide N-methyltransferase) belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. It is predominantly expressed in the liver, and a lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. NNMT catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds. Recombinant human NNMT protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
products references :
Parsons RB., et al. (2002). J Neuropathol Exp Neurol. 61(2):111-24. Smith ML., et al. (1998). Biochim Biophys Acta. 1442(2-3):238-44.
ncbi gi num :
5453790
ncbi acc num :
NP_006160
ncbi gb acc num :
NM_006169.2
ncbi mol weight :
31.7 kDa (284aa), confirmed by MALDI-TOF.
ncbi pathways :
Biological Oxidations Pathway (105698); Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway (1127639); Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway (1127658); Defective GGT1 Causes Glutathionuria (GLUTH) Pathway (1127659); Defective GSS Causes Glutathione Synthetase Deficiency (GSS Deficiency) Pathway (1127660); Defective MAT1A Causes Methionine Adenosyltransferase Deficiency (MATD) Pathway (1127663); Defective OPLAH Causes 5-oxoprolinase Deficiency (OPLAHD) Pathway (1127661); Defective SLC35D1 Causes Schneckenbecken Dysplasia (SCHBCKD) Pathway (1127665); Defective TPMT Causes Thiopurine S-methyltransferase Deficiency (TPMT Deficiency) Pathway (1127666); Defective UGT1A1 Causes Hyperbilirubinemia Pathway (1127667)
ncbi summary :
N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 2008]
uniprot summary :
NNMT: Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds. Belongs to the NNMT/PNMT/TEMT family. Protein type: Methyltransferase; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 2.1.1.1. Chromosomal Location of Human Ortholog: 11q23.1. Cellular Component: cytosol. Molecular Function: nicotinamide N-methyltransferase activity. Biological Process: methylation; response to drug; organ regeneration; xenobiotic metabolic process; response to organic nitrogen
size1 :
0.1 mg
price1 :
310 USD
size2 :
0.5 mg
price2 :
720
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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