catalog number :
MBS203313
products type :
Recombinant Protein
products full name :
Pentraxin 3, 18-381aa, Human, His-tag, Recombinant, E Coli
products short name :
Pentraxin 3
products name syn :
TNFAIP5; TSG-14; Pentraxin 3; AI607804; Pentaxin 3; Pentaxin-related protein PTX3; Pentraxin-related gene; rapidly induced by IL-1 beta; Pentraxin-related gene; PTX3; TSG14; Tumor necrosis factor-inducible gene 14 protein; Tumor necrosis factor-inducible protein TSG-14
other names :
pentraxin-related protein PTX3; Pentraxin-related protein PTX3; pentraxin-related protein PTX3; TNF alpha-induced protein 5; pentaxin-related gene, rapidly induced by IL-1 beta, tumor necrosis factor, alpha-induced protein 5; pentaxin-related protein PTX3; pentraxin-3; pentraxin-related gene, rapidly induced by IL-1 beta; tumor necrosis factor alpha-induced protein 5; tumor necrosis factor-inducible gene 14 protein; tumor necrosis factor-inducible protein TSG-14; pentraxin 3, long; Pentaxin-related protein PTX3; Tumor necrosis factor alpha-induced protein 5; TNF alpha-induced protein 5; Tumor necrosis factor-inducible gene 14 protein; TSG-14
other gene names :
PTX3; PTX3; TSG-14; TNFAIP5; TNFAIP5; TSG14; TNF alpha-induced protein 5; TSG-14
uniprot entry name :
PTX3_HUMAN
sequence :
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMENS DDYDLMYVNL DNEIDNGLHP TEDPTPCDCG QEHSEWDKLF IMLENSQMRE RMLLQATDDV LRGELQRLRE ELGRLAESLA RPCAPGAPAE ARLTSALDEL LQATRDAGRR LARMEGAEAQ RPEEAGRALA AVLEELRQTR ADLHAVQGWA ARSWLPAGCE TAILFPMRSK KIFGSVHPVR PMRLESFSAC IWVKATDVLN KTILFSYGTK RNPYEIQLYL SYQSIVFVVG GEENKLVAEA MVSLGRWTHL CGTWNSEEGL TSLWVNGELA ATTVEMATGH IVPEGGILQI GQEKNGCCVG GGFDETLAFS GRLTGFNIWD SVLSNEEIRE TGGAESCHIR GNIVGWGVTE IQPHGGAQYV S
purity :
> 90% by SDS - PAGE
form :
Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT 10% glycerol.
concentration :
1 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human. Tag: His-tag
other info2 :
Expression System: E Coli
products categories :
Immunology
products description :
Pentraxin 3(PTX3) is the prototypic member of the long pentraxin family sharing the C-terminal domain with short pentraxins and containing a unique N-terminal domain. Pentraxin 3 is produced and released at inflammatory sites by diverse cell types including monocytes/macrophages, endothelial cells, vascular smooth muscle cells, fibroblasts, and adipocytes. It plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. Recombinant human Pentraxin 3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
products references :
Imamura M., et al. (2007). Cell Immunol. 248(2):86-94. Allens VV., et al. (1994). Blood. 84(10):3483-93.
ncbi gb acc num :
NM_002852.3
ncbi mol weight :
44.4 kDa (401aa), confirmed by MALDI-TOF.
uniprot summary :
PTX3: Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self- components and female fertility. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 3q25. Cellular Component: extracellular space; extracellular region. Molecular Function: complement component C1q binding; zymosan binding; virion binding. Biological Process: positive regulation of nitric oxide biosynthetic process; negative regulation of virion penetration into host cell; positive regulation of phagocytosis; innate immune response; response to yeast; opsonization; inflammatory response