protein

Osteoprotegerin/TNFRSF11B, 22-401aa, Human, His-tag, Recombinant, Hi-5 cell

MBS203305

0.03 mg

375 USD

Recombinant Protein

Osteoprotegerin/TNFRSF11B, 22-401aa, Human, His-tag, Recombinant, Hi-5 cell

Osteoprotegerin/TNFRSF11B

Osteoclastogenesis inhibitory factor; OPG; OCIF; Tumor necrosis factor receptor superfamily; member 11b MGC29565; TNFRSF 11B; TNFRSF11B; TR 1; TR1; Tumor Necrosis Factor Receptor Superfamily Member 11b.

tumor necrosis factor receptor superfamily member 11B; Tumor necrosis factor receptor superfamily member 11B; tumor necrosis factor receptor superfamily member 11B; osteoclastogenesis inhibitory factor; osteoprotegerin; tumor necrosis factor receptor superfamily, member 11b; Osteoclastogenesis inhibitory factor; Osteoprotegerin

TNFRSF11B; TNFRSF11B; OPG; TR1; OCIF; OCIF; OPG

TR11B_HUMAN

401

ADPETFPPKY LHYDEETSHQ LLCDKCPPGT YLKQHCTAKW KTVCAPCPDH YYTDSWHTSD ECLYCSPVCK ELQYVKQECN RTHNRVCECK EGRYLEIEFC LKHRSCPPGF GVVQAGTPER NTVCKRCPDG FFSNETSSKA PCRKHTNCSV FGLLLTQKGN ATHDNICSGN SESTQKCGID VTLCEEAFFR FAVPTKFTPN WLSVLVDNLP GTKVNAESVE RIKRQHSSQE QTFQLLKLWK HQNKDQDIVK KIIQDIDLCE NSVQRHIGHA NLTFEQLRSL MESLPGKKVG AEDIEKTIKA CKPSDQILKL LSLWRIKNGD QDTLKGLMHA LKHSKTYHFP KTVTQSLKKT IRFLHSFTMY KLYQKLFLEM IGNQVQSVKI SCLSGRLVPR GSHHHHHH

> 85 % by SDS - PAGE

Liquid. In PBS (pH 7.4) containing 10% glycerol

0.5 mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human. Tag: His-tag

Expression System: Hi-5. Endotoxin: < 1.0 Eu per 1 microgram of protein (determined by LAL method)

Hormones & Cytokines

Osteoprotegerin (OPG) is a member of the tumor necrosis factor (TNF)-related family, is referred to as TNFRSF11B and part of the OPG/receptor activator of NF-kB ligand (RANKL)/receptor activator of NF-kB (RANK) triad. This cytokine that lacks any apparent cell-association motifs and exists as a soluble secreted protein, network regulates the differentiation and activation of osteoclasts and hence the critical balance between bone formation (osteoblasts) and bone resorption (osteoclasts). Recombinant human osteoprotegerin protein, fused to His-tag at C-terminus, was expressed in Hi-5 cell using baculovirus expression system and purified by using conventional chromatography techniques.

Lacey, D.L. et al. (1998) Cell 93:165-76. Yasuda H. et al. (1998) PNAS 95:3597-602 . A. Van Campenhout, Golledge J. (2009) Atherosclerosis 204:321-29.

148743793

NP_002537

NM_002546.3

45.6 kDa (398 aa) (Molecular weight on SDS-PAGE will appear higher)

Apoptosis Modulation And Signaling Pathway 198822!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Monoamine Transport Pathway 198851!!Osteoblast Signaling Pathway 198842!!Osteoclast Signaling Pathway 198769!!Osteoclast Differentiation Pathway 193147!!Osteoclast Differentiation Pathway 193096!!RANKL/RANK Signaling Pathway 672447

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

0.03 mg

375 USD