catalog number :
MBS2033046
products type :
Recombinant Protein
products full name :
Recombinant 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase (CNP)
products short name :
[2',3'-Cyclic Nucleotide 3'-Phosphodiesterase]
products name syn :
[2,3CNP; 2,3-CNP; CNPCNP1; Cyclic-CMP Phosphodiesterase; 2',3'-Cyclic AMP Phosphodiesterase; CNPase; 2':3'-CNMP-3'-ase]
other names :
[2',3'-cyclic-nucleotide 3'-phosphodiesterase; 2',3'-cyclic-nucleotide 3'-phosphodiesterase; 2',3'-cyclic-nucleotide 3'-phosphodiesterase; 2',3'-cyclic nucleotide 3' phosphodiesterase]
products gene name :
[CNP]
other gene names :
[Cnp; Cnp; CNPF; CNPI; Cnp1; CNPII; Cnp1; CNP; CNPase]
uniprot entry name :
CN37_RAT
sequence :
LPLYF GWFLTKKSSE TLRKAGQVFL EELGNHKAFK KELRQFVPGD EPREKMDLVT YFGKRPPGVL HCTTKFCDYG KAPGAEEYAQ QDVLKKSYSK AFTLTISALF VTPKTTGARV ELSEQQLQLW PSDVDKLSPT DNLPRGSRAH ITLGCAADVE AVQTGLDLLE ILRQEKGGSR GEEVGELSRG KLYSLGNGRW MLTLAKNMEV RAIFTGYYGK GKPVPTQGSR KGGALQSCTII
form :
20mM Tris, 150mM NaCl, pH8.0, containing 0.01% SKL, 5% Trehalose.
concentration :
Original Concentration: 600ug/mL
storage stability :
Storage: Avoid repeated freeze/thaw cycles. Store at 2-8ºC for one month. Aliquot and store at -80ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
tested application :
Positive Control; Immunogen; SDS-PAGE; Western Blot (WB). (May be suitable for use in other assays to be determined by the end user.)
image1 heading :
SDS-Page
other info1 :
Organism Species: Homo sapiens (Human). Source: Prokaryotic expression. Residues: Leu186~Ile421. Tags: N-terminal His Tag. Subcellular Location: Membrane. Traits: Freeze-dried powder. Predicted isoelectric point: 9.3. Usage: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
ncbi acc num :
NP_036941.1
ncbi gb acc num :
NM_012809.2
ncbi mol weight :
Predicted Molecular Mass: 29.8kDa. Accurate Molecular Mass: 30kDa as determined by SDS-PAGE reducing conditions.
ncbi summary :
microtubule-binding protein that promotes microtubule assembly and may regulate cellular distribution of microtubules [RGD, Feb 2006]
uniprot summary :
CNP: May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin. Exists as monomers and homodimers. Belongs to the cyclic nucleotide phosphodiesterase family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Phosphodiesterase; EC 3.1.4.37; Cell development/differentiation. Cellular Component: cell projection; cytoplasm; extracellular space; melanosome; membrane; microtubule; microvillus; mitochondrial inner membrane; mitochondrial outer membrane; myelin sheath; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; pseudopodium. Molecular Function: 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity; cyclic nucleotide binding; RNA binding. Biological Process: adult locomotory behavior; aging; axonogenesis; cyclic nucleotide catabolic process; forebrain development; microtubule cytoskeleton organization and biogenesis; oligodendrocyte differentiation; regulation of mitochondrial membrane permeability; response to lipopolysaccharide; response to toxin; substantia nigra development