FABP2, 1-132aa, Human, His-tag, Recombinant, E Coli | MyBioSource MBS203299 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

FABP2, 1-132aa, Human, His-tag, Recombinant, E Coli

catalog :

MBS203299

quantity :

0.1 mg

price :

290 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS203299

products type :

Recombinant Protein

products full name :

FABP2, 1-132aa, Human, His-tag, Recombinant, E Coli

products short name :

FABP2

products name syn :

Intestinal fatty acid binding protein 2; FABPI; I-FABP; Intestinal fatty acid binding protein 2 FABP 2; FABP2; Fatty acid binding protein; Fatty acid binding protein 2 intestinal; Fatty acid binding protein intestinal; I FABP; IFABP; Intestinal fatty acid binding protein 2; MGC133132; Fatty Acid Binding Protein-2

other names :

fatty acid-binding protein, intestinal; Fatty acid-binding protein, intestinal; fatty acid-binding protein, intestinal; fatty acid-binding protein 2; intestinal-type fatty acid-binding protein; fatty acid binding protein 2, intestinal; Fatty acid-binding protein 2; Intestinal-type fatty acid-binding protein; I-FABP

products gene name :

FABP2

other gene names :

FABP2; FABP2; FABPI; I-FABP; FABPI; I-FABP

uniprot entry name :

FABPI_HUMAN

sequence length :

132

sequence :

MGSSHHHHHH SSGLVPRGSH MAFDSTWKVD RSENYDKFME KMGVNIVKRK LAAHDNLKLT ITQEGNKFTV KESSAFRNIE VVFELGVTFN YNLADGTELR GTWSLEGNKL IGKFKRTDNG NELNTVREII GDELVQTYVY EGVEAKRIFK KD

purity :

> 95% by SDS - PAGE

form :

Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

concentration :

1 mg/ml (determined by Bradford assay)

storage stability :

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

tested application :

SDS-PAGE

other info1 :

Antigen Species: Human. Tag: His-tag

other info2 :

Expression System: E Coli. Endotoxin: < 1.0 Eu per 1 microgram of protein (determined by LAL method)

products categories :

Transportation

products description :

FABP2, also known as intestinal fatty acid binding protein 2 (I-FABP), is expressed in the epithelium of the small intestine by mature enterocytes. FABP2 is thought to facilitate of cellular uptake and transport of long-chain fatty acids within enterocytes and may also help maintain energy homeostasis by functioning as a lipid sensor. This protein binds saturated long-chain fatty acid with a high affinity, but binds with a low affinity to unsaturated long-chain fatty acid. The Ala to Thr substitution at residue 54 of FABP2 is associated with higher total cholesterol, with stroke incidence, elevation of fasting and postprandial triglyceride, insulin resistance, and higher nonesterified fatty acid (NEFA) concentrations. Recombinant human FABP2, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

products references :

Baier LJ., et al. (1995). J Clin Invest. 95(3):1281-7. Helwig u., et al. (2007) Metabolism. 56(6):723-31.

ncbi gi num :

194097325

ncbi acc num :

NP_000125

ncbi gb acc num :

NM_000134.3

ncbi mol weight :

17.3 kDa (152 aa), confirmed by MALDI-TOF.

ncbi pathways :

Fat Digestion And Absorption Pathway (194385); Fat Digestion And Absorption Pathway (194324); PPAR Signaling Pathway (83042); PPAR Signaling Pathway (450)

ncbi summary :

The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells. This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance. [provided by RefSeq, Jul 2008]

uniprot summary :

FABP2: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long- chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. Chromosomal Location of Human Ortholog: 4q28-q31. Cellular Component: cytoplasm. Molecular Function: transporter activity; fatty acid binding. Biological Process: transport; digestion

size1 :

0.1 mg

price1 :

290 USD

size2 :

0.5 mg

price2 :

650

more info or order :

MyBioSource product webpage