CBR1, 1-277aa, Human, Recombinant, E Coli | MyBioSource MBS203291 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

CBR1, 1-277aa, Human, Recombinant, E Coli

catalog :

MBS203291

quantity :

0.1 mg

price :

310 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS203291

products type :

Recombinant Protein

products full name :

CBR1, 1-277aa, Human, Recombinant, E Coli

products short name :

CBR1

products name syn :

Carbonyl reductase 1; CBR; hCBR1; SDR21C1; CBR1; Carbonyl reductase 1 15 hydroxyprostaglandin dehydrogenase [NADP+]; Carbonyl reductase [NADPH] 1.CBR 1; CRN; NADPH dependent carbonyl reductase 1; Prostaglandin 9 ketoreductase; Prostaglandin E(2) 9 reductase.

other names :

carbonyl reductase; Carbonyl reductase [NADPH] 1; carbonyl reductase [NADPH] 1; carbonyl reductase [NADPH] 1; 15-hydroxyprostaglandin dehydrogenase; NADPH-dependent carbonyl reductase 1; carbonyl reductase (NADPH) 1; prostaglandin 9-ketoreductase; prostaglandin-E(2) 9-reductase; short chain dehydrogenase/reductase family 21C, member 1; carbonyl reductase 1; 15-hydroxyprostaglandin dehydrogenase [NADP(+)] (EC:1.1.1.197); NADPH-dependent carbonyl reductase 1; Prostaglandin 9-ketoreductase; Prostaglandin-E(2) 9-reductase (EC:1.1.1.189)

products gene name :

CBR1

other gene names :

CBR1; CBR1; CBR; hCBR1; SDR21C1; CBR; CRN

uniprot entry name :

CBR1_HUMAN

sequence length :

277

sequence :

MSSGIHVALV TGGNKGIGLA IVRDLCRLFS GDVVLTARDV TRGQAAVQQL QAEGLSPRFH QLDIDDLQSI RALRDFLRKE YGGLDVLVNN AGIAFKVADP TPFHIQAEVT MKTNFFGTRD VCTELLPLIK PQGRVVNVSS IMSVRALKSC SPELQQKFRS ETITEEELVG LMNKFVEDTK KGVHQKEGWP SSAYGVTKIG VTVLSRIHAR KLSEQRKGDK ILLNACCPGW VRTDMAGPKA TKSPEEGAET PVYLALLPPD AEGPHGQFVS EKRVEQW

purity :

> 95% by SDS - PAGE

form :

Liquid. In 20 mM Tris-HCl buffer (pH 8.5) containing 10% glycerol

concentration :

1 mg/ml (determined by Bradford assay)

storage stability :

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

tested application :

SDS-PAGE

other info1 :

Antigen Species: Human

other info2 :

Expression System: E Coli

products categories :

Redox Proteins

products description :

CBR1(Carbonyl reductase 1) is one of several monomeric NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds. CBR1 is widely distributed in human tissues. CBR1 metabolizes many toxic environmental quinones and pharmacological relevant substrates such as the anticancer doxorubicin. CBR1 can also convert prostaglandin E2 to prostaglandin F2-alpha. Recombinant human CBR1 protein was expressed in E.coli and purified by using conventional chromatography.

products references :

Bateman RL., et al. (2008), J Biol Chem. 283(51):35756-62. Plebuch M., et al. (2007). Cancer Lett. 255(1):49-56.

ncbi gi num :

4502599

ncbi acc num :

NP_001748

ncbi gb acc num :

NM_001757.3

ncbi mol weight :

30 kDa (277aa), confirmed by MALDI-TOF.

ncbi pathways :

Arachidonic Acid Metabolism Pathway (82991); Arachidonic Acid Metabolism Pathway (685553); Arachidonic Acid Metabolism Pathway (366); Chemical Carcinogenesis Pathway (673221); Chemical Carcinogenesis Pathway (673237); Metabolic Pathways (132956); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); Metabolism Of Xenobiotics By Cytochrome P450 Pathway (83031); Metabolism Of Xenobiotics By Cytochrome P450 Pathway (425)

ncbi summary :

The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]

uniprot summary :

CBR1: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. Belongs to the short-chain dehydrogenases/reductases (SDR) family. Protein type: EC 1.1.1.189; EC 1.1.1.184; Lipid Metabolism - arachidonic acid; EC 1.1.1.197; Oxidoreductase. Chromosomal Location of Human Ortholog: 21q22.13. Cellular Component: cytosol; vesicle. Molecular Function: oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor; prostaglandin-E2 9-reductase activity; 15-hydroxyprostaglandin dehydrogenase (NADP+) activity; carbonyl reductase (NADPH) activity. Biological Process: epithelial cell differentiation; vitamin K metabolic process; cyclooxygenase pathway; arachidonic acid metabolic process; drug metabolic process

size1 :

0.1 mg

price1 :

310 USD

size2 :

0.5 mg

price2 :

720

more info or order :

MyBioSource product webpage