product summary
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company name :
MyBioSource
product type :
protein
product name :
Glutaredoxin-1,1-106aa, Human, Recombinant, E Coli
catalog :
MBS203286
quantity :
0.1 mg
price :
255 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS203286
products type :
Recombinant Protein
products full name :
Glutaredoxin-1,1-106aa, Human, Recombinant, E Coli
products short name :
Glutaredoxin-1
products name syn :
GLRX; GRX; GRX1; Thioltransferase-1; TTase-1; Glrx1; Glutaredoxin; Glutaredoxin1; Grx 1; MGC117407; Thioltransferase; Thioltransferase 1; Thioltransferase1; Ttase; TTase 1; TTase1.
other names :
glutaredoxin-1; Glutaredoxin-1; glutaredoxin-1; TTase-1; thioltransferase-1; glutaredoxin (thioltransferase); Thioltransferase-1; TTase-1
other gene names :
GLRX; GLRX; GRX; GRX1; GRX; TTase-1
uniprot entry name :
GLRX1_HUMAN
sequence length :
106
sequence :
MAQEFVNCKI QPGKVVVFIK PTCPYCRRAQ EILSQLPIKQ GLLEFVDITA TNHTNEIQDY LQQLTGARTV PRVFIGKDCI GGCSDLVSLQ QSGELLTRLK QIGALQ
purity :
> 95% by SDS - PAGE
form :
Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT 10% glycerol
concentration :
1 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human
other info2 :
Expression System: E Coli
products categories :
Redox Proteins
products description :
Description: Glutaredoxin(GRX), also known as thioltransferase, is member of the thiol-disulfide oxidoreductase family. Glutraredoxin catalyzes the reversible reduction of protein-glutathionyl mixed disulfides to free sulfhydryl groups though a monothiol mechanism. Mammalian Glutaredoxin is known to have two isoforms, GRX1 and GRX2. GRX1 is a cytosolic protein, whereas GRX2 is localized both in the mitochondria and nucleus. Glutaredoxin-1 may be involved in a various cellular events such as signal transduction, stress response, and metabolic regulation by regulating the redox status of cellular proteins. Recombinant human Glutaredoxin1 protein was expressed in E.coli and purified by using conventional chromatography techniques.
products references :
Reynaert NL., et al. (2006) Proc Natl Acad Sci u S A. 103(35):13086-91. Kanda M., et al. (2006) J Biol Chem. 281(39):28518-28.
ncbi gi num :
4504025
ncbi acc num :
NP_002055
ncbi gb acc num :
NM_002064.2
ncbi mol weight :
11.7 kDa (106 aa), confirmed by MALDI-TOF.
ncbi pathways :
Metabolism Pathway (477135); Metabolism Of Nucleotides Pathway (106263); Synthesis And Interconversion Of Nucleotide Di- And Triphosphates Pathway (161057); Ascorbate Recycling (cytosolic) Pathway (545345); Ascorbate Recycling (cytosolic) Pathway (545621)
ncbi summary :
This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]
uniprot summary :
GLRX1: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. Belongs to the glutaredoxin family. Protein type: Oxidoreductase. Chromosomal Location of Human Ortholog: 5q14. Cellular Component: mitochondrion; nucleus; cytosol. Molecular Function: electron carrier activity; protein N-terminus binding; glutathione disulfide oxidoreductase activity. Biological Process: nucleobase, nucleoside and nucleotide interconversion; nucleobase, nucleoside and nucleotide metabolic process; cell redox homeostasis; positive regulation of membrane potential
size1 :
0.1 mg
price1 :
255 USD
size2 :
0.5 mg
price2 :
535
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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