product summary
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company name :
MyBioSource
product type :
protein
product name :
GRB2, 1-217aa, Human, His-tag, Recombinant, E Coli
catalog :
MBS203275
quantity :
0.1 mg
price :
310 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS203275
products type :
Recombinant Protein
products full name :
GRB2, 1-217aa, Human, His-tag, Recombinant, E Coli
products short name :
GRB2
products name syn :
Growth factor receptor-bound protein 2 isoform 1; ASH; EGFRBP-GRB2; GRB3-3; Growth factor receptor-bound protein 2 isoform 1 Abundant SRC homology; Adapter protein GRB2; Ash protein; EGFRBP GRB2; Epidermal growth factor receptor binding protein; Epidermal growth factor receptor binding protein GRB2; GRB 2; GRB2 adapter protein; Grb3 3; Growth factor receptor bound protein 2; Growth factor receptor bound protein 3; HT027; MST084; MSTP084; OTTHuMP00000166096; OTTHuMP00000166097; OTTHuMP00000166098; Protein ASH; SEM5; SH2/SH3 adapter GRB2.
other names :
growth factor receptor-bound protein 2 isoform 1; Growth factor receptor-bound protein 2; growth factor receptor-bound protein 2; HT027; SH2/SH3 adapter GRB2; abundant SRC homology; epidermal growth factor receptor-binding protein GRB2; growth factor receptor-bound protein 3; protein Ash; growth factor receptor-bound protein 2; Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2
products gene name :
GRB2
other gene names :
GRB2; GRB2; ASH; Grb3-3; MST084; NCKAP2; MSTP084; EGFRBP-GRB2; ASH
uniprot entry name :
GRB2_HUMAN
sequence length :
217
sequence :
MGSSHHHHHH SSGLVPRGSH MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQVPQQPTY VQALFDFDPQ EDGELGFRRG DFIHVMDNSD PNWWKGACHG QTGMFPRNYV TPVNRNV
purity :
> 95% by SDS - PAGE
form :
In 20mM Tris-HCl (pH8.0) buffer containing 30% glycerol
concentration :
1 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human. Tag: His-tag
other info2 :
Expression System: E Coli
products categories :
Signal Transduction
products description :
Growth factor receptor-bound protein 2 also known as Grb2 is an adaptor protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. GRB2 is widely expressed and also binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Grb2 is composed of an SH2 domain flanked on each side by an SH3 domain. Inhibition of Grb2 function impairs developmental processes in various organisms and blocks transformation and proliferation of various cell types. Recombinant human GRB2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
products references :
Rudd CE., et al. (2009) Immunol Rev. 229(1):12-26. Weisswange I., et al. (2009) Nature. 458(7234):87-91.
ncbi gi num :
4504111
ncbi acc num :
NP_002077
ncbi gb acc num :
NM_002086.4
ncbi mol weight :
27 kDa (237 aa), confirmed by MALDI-TOF.
ncbi pathways :
Acute Myeloid Leukemia Pathway (83117); Acute Myeloid Leukemia Pathway (529); Adaptive Immune System Pathway (366160); Alcoholism Pathway (585563); Alcoholism Pathway (587116); Alpha6-Beta4 Integrin Signaling Pathway (198807); Angiopoietin Receptor Tie2-mediated Signaling Pathway (137917); Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway (576249); Axon Guidance Pathway (105688); B Cell Receptor Signaling Pathway (198909)
ncbi summary :
The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
size1 :
0.1 mg
price1 :
310 USD
size2 :
0.5 mg
price2 :
720
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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