N-Acetyltransferase 8 Like Protein (NAT8L) Polyclonal Antibody | MyBioSource MBS2032599 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

N-Acetyltransferase 8 Like Protein (NAT8L) Polyclonal Antibody

catalog :

MBS2032599

quantity :

0.01 mg

price :

115 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot: Sample: Recombinant protein.

image 2 :

DAB staining on fromalin fixed paraffin- embedded brain tissue)

product information

catalog number :

MBS2032599

products type :

Antibody

products full name :

N-Acetyltransferase 8 Like Protein (NAT8L) Polyclonal Antibody

products short name :

[N-Acetyltransferase 8 Like Protein]

products name syn :

[Hcml3; CML3; NAA synthetase; N-acetylaspartate synthetase; Camello-like protein 3]

other names :

[N-acetylaspartate synthetase; N-acetylaspartate synthetase; N-acetylaspartate synthetase; N-acetyltransferase 8 like; Camello-like protein 3; N-acetyltransferase 8-like protein]

products gene name :

[NAT8L]

other gene names :

[NAT8L; NAT8L; CML3; NACED; NAT8-LIKE; CML3; NAA synthetase]

clonality :

Polyclonal

host :

Rabbit

purity :

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

form :

Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300,50% glycerol.

concentration :

0.57 mg/ml

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP).

app notes :

Western blotting: 0.5-2 ug/mL;1:280-1100. Immunohistochemistry: 5-20 ug/mL;1:28-110. Immunocytochemistry: 5-20 ug/mL;1:28-110. Optimal working dilutions must be determined by end user.

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Organism Species: Homo sapiens (Human). Source: Polyclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant NAT8L (Met1~Glu302) expressed in E.coli

ncbi gi num :

263192221

ncbi acc num :

NP_848652.2

ncbi gb acc num :

NM_178557.3

uniprot acc num :

Q8N9F0

ncbi pathways :

Alanine, Aspartate And Glutamate Metabolism Pathway (101142); Alanine, Aspartate And Glutamate Metabolism Pathway (100063); Metabolic Pathways (132956); Metapathway Biotransformation (198837)

ncbi summary :

This gene encodes a single-pass membrane protein, which contains a conserved sequence of the GCN5 or NAT superfamily of N-acetyltransferases and is a member of the N-acyltransferase (NAT) superfamily. This protein is a neuron-specific protein and is the N-acetylaspartate (NAA) biosynthetic enzyme, catalyzing the NAA synthesis from L-aspartate and acetyl-CoA. NAA is a major storage and transport form of acetyl coenzyme A specific to the nervous system. The gene mutation results in primary NAA deficiency (hypoacetylaspartia). [provided by RefSeq, Dec 2010]

uniprot summary :

NAT8L: Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake. Defects in NAT8L are the cause of N-acetylaspartate deficiency (NACED). A metabolic disorder resulting in truncal ataxia, marked developmental delay, seizures, and secondary microcephaly. Belongs to the camello family. Protein type: Acetyltransferase; EC 2.3.1.17; Membrane protein, integral. Chromosomal Location of Human Ortholog: 4p16.3. Cellular Component: cytoplasm; integral component of membrane; mitochondrial matrix; mitochondrial membrane; mitochondrion; rough endoplasmic reticulum membrane. Molecular Function: aspartate N-acetyltransferase activity. Biological Process: amino acid biosynthetic process. Disease: N-acetylaspartate Deficiency

size1 :

0.01 mg

price1 :

115 USD

size2 :

0.02 mg

price2 :

135

size3 :

0.05 mg

price3 :

190

size4 :

0.1 mg

price4 :

245

size5 :

0.2 mg

price5 :

370

size6 :

1 mg

price6 :

880

more info or order :

MyBioSource product webpage