catalog number :
MBS2032540
products full name :
Aggrecan (AGC) Polyclonal Antibody
products short name :
[Aggrecan]
products name syn :
[ACAN; AGC1; AGCAN; CSPG1; CSPCP; CSPGCP; MSK16; SEDK; Cartilage-specific proteoglycan core protein; Large Aggregating Proteoglycan; Chondroitin Sulfate Proteoglycan 1]
other names :
[aggrecan core protein; Aggrecan core protein; aggrecan core protein; aggrecan; Cartilage-specific proteoglycan core protein; CSPCP]
products gene name :
[AGC]
other gene names :
[ACAN; ACAN; AGC1; AGC1; CSPCP]
purity :
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
form :
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
storage stability :
Storage: Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the
expiration date under appropriate storage condition.
tested application :
WB; IHC; ICC; IP.
app notes :
Western blotting: 0.5-2 ug/mL;1:500-2000. Immunohistochemistry: 5-20 ug/mL;1:50-200. Immunocytochemistry: 5-20 ug/mL;1:50-200. Optimal working dilutions must be determined by end user.
image1 heading :
Western Blot (WB)
other info1 :
Organism Species: Bos taurus; Bovine (Cattle). Source: Polyclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant AGC (Glu2066~Arg2316 (Accession # P13608)) expressed in E.coli
other info2 :
Conjugated Antibody: The APC conjugated antibody version of this item is also available as catalog #MBS2060470
ncbi acc num :
NP_776406.1
ncbi gb acc num :
NM_173981.2
ncbi pathways :
Glycosaminoglycan Metabolism Pathway (637152); Keratan Sulfate Biosynthesis Pathway (637157); Keratan Sulfate Degradation Pathway (637158); Keratan Sulfate/keratin Metabolism Pathway (637156); Metabolism Pathway (637141); Metabolism Of Carbohydrates Pathway (637142)
uniprot summary :
This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.