protein

PAK4, 1-591aa, Human, His-tag, Recombinant, E Coli

MBS203242

0.1 mg

375 USD

Recombinant Protein

PAK4, 1-591aa, Human, His-tag, Recombinant, E Coli

PAK4

p21 protein (Cdc42/Rac)-activated kinase 4; Serine/threonine-protein kinase; PAK 4; p21 activated kinase 4 isoform 1; p21-activated kinase 4 isoform 1 KIAA1142; p21 activated kinase 4; p21(CDKN1A) activated kinase 4; Protein kinase related to S.cerevisiae STE20 effector for Cdc42Hs; Serine threonine kinase PAK 4; Serine/threonine protein kinase PAK 4; Serine/threonine protein kinase PAK4.

serine/threonine-protein kinase PAK 4 isoform 1; Serine/threonine-protein kinase PAK 4; serine/threonine-protein kinase PAK 4; PAK-4; p21(CDKN1A)-activated kinase 4; p21-activated kinase 4; protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs; p21 protein (Cdc42/Rac)-activated kinase 4; p21-activated kinase 4; PAK-4

PAK4

PAK4; PAK4; KIAA1142; PAK-4

PAK4_HUMAN

591

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMFG KRKKRVEISA PSNFEHRVHT GFDQHEQKFT GLPRQWQSLI EESARRPKPL VDPACITSIQ PGAPKTIVRG SKGAKDGALT LLLDEFENMS VTRSNSLRRD SPPPPARARQ ENGMPEEPAT TARGGPGKAG SRGRFAGHSE AGGGSGDRRR AGPEKRPKSS REGSGGPQES SRDKRPLSGP DVGTPQPAGL ASGAKLAAGR PFNTYPRADT DHPSRGAQGE PHDVAPNGPS AGGLAIPQSS SSSSRPPTRA RGAPSPGVLG PHASEPQLAP PACTPAAPAV PGPPGPRSPQ REPQRVSHEQ FRAALQLVVD PGDPRSYLDN FIKIGEGSTG IVCIATVRSS GKLVAVKKMD LRKQQRRELL FNEVVIMRDY QHENVVEMYN SYLVGDELWV VMEFLEGGAL TDIVTHTRMN EEQIAAVCLA VLQALSVLHA QGVIHRDIKS DSILLTHDGR VKLSDFGFCA QVSKEVPRRK SLVGTPYWMA PELISRLPYG PEVDIWSLGI MVIEMVDGEP PYFNEPPLKA MKMIRDNLPP RLKNLHKVSP SLKGFLDRLL VRDPAQRATA AELLKHPFLA KAGPPASIVP LMRQNRTR

> 90% by SDS - PAGE

Liquid. 25mM HEPES pH7.5, 150mM NaCl, 5mM MgCl2, 30% glycerol.

0.5 mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human. Tag: His-tag

Expression System: E Coli. Endotoxin: < 1.0 Eu per 1 microgram of protein (determined by LAL method)

Cancer

PAK4 is a member of the group B family of p21-activated kinases (PAK). It's identified as an effector protein for cell division cycle 42(Cdc42) and protein that play an important role in regulating cytoskeletal organization and cell morphology. Its expression is elevated in many cancer cell lines, and suggested that it plays an important role in tumorigenesis. Recombinant PAK4 protein was expressed in E.coli and purified by using conventional chromatography techniques.

Liu Y., et al. (2008). Mol Cancer Res. 6(7):1215-24. Li X., et al. (2005). J Biol Chem. 280(50):41192-200.

62422554

NP_001014831

NM_001014831.2

68.3 kDa (628 aa)

Activation Of Rac Pathway 119530!!Axon Guidance Pathway 83065!!Axon Guidance Pathway 476!!Axon Guidance Pathway 105688!!CDC42 Signaling Events Pathway 137994!!Developmental Biology Pathway 477129!!ErbB Signaling Pathway 198844!!ErbB Signaling Pathway 83049!!ErbB Signaling Pathway 458!!FGF Signaling Pathway 137989

PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

0.1 mg

375 USD