product summary
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company name :
MyBioSource
product type :
protein
product name :
KISS1, 1-120aa, Human, Recombinant, E Coli
catalog :
MBS203241
quantity :
0.1 mg
price :
310 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS203241
products type :
Recombinant Protein
products full name :
KISS1, 1-120aa, Human, Recombinant, E Coli
products short name :
KISS1
products name syn :
METASTIN; MGC39258; KiSS-1 metastasis-suppressor; Kisspeptin-1; KISS1; KiSS-1 metastasis-suppressor
other names :
metastasis-suppressor KiSS-1 preproprotein; Metastasis-suppressor KiSS-1; metastasis-suppressor KiSS-1; kisspeptin-1; malignant melanoma metastasis-suppressor; metastin; prepro-kisspeptin; KiSS-1 metastasis-suppressor; Kisspeptin-1Cleaved into the following 4 chains:MetastinAlternative name(s):Kisspeptin-54
products gene name :
KISS1
other gene names :
KISS1; KISS1; HH13; KiSS-1
uniprot entry name :
KISS1_HUMAN
sequence length :
138
sequence :
MEPLEKVASV GNSRPTGQQL ESLGLLAPGE QSLPCTERKP AATARLSRRG TSLSPPPESS GSPQQPGLSA PHSRQIPAPQ GAVLVQREKD LPNYNWNSFG LRFGKREAAP GNHGRSAGRG
purity :
> 90% by SDS - PAGE
form :
Liquid in 20mM Tris pH 8.0, 1mM DTT, 10% glycerol
concentration :
1 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human
other info2 :
Expression System: E Coli
products categories :
Cancer
products description :
KiSS-1 metastasis-suppressor (KISS1) is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. Expression of KiSS1 has been localized to specific regions of the hypothalamus in many species and is regulated by gonadal steroids and across the estrous cycle. Recombinant KISS1 protein was expressed in E.coli and purified by using conventional chromatography techniques.
products references :
Harms JF., et al. (2003) Clin Exp Metastasis. 1(1):11-8. Smith JT.,. (2007) Rev Endocr Metab Disord. 8(1):1-9.
ncbi gi num :
116829964
ncbi acc num :
NP_002247
ncbi gb acc num :
NM_002256.3
ncbi mol weight :
12.6 kDa (120 aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher)
ncbi pathways :
Class A/1 (Rhodopsin-like Receptors) Pathway 106357!!Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway 1127664!!Disease Pathway 530764!!G Alpha (q) Signalling Events Pathway 106043!!GPCR Downstream Signaling Pathway 119548!!GPCR Ligand Binding Pathway 161020!!Gastrin-CREB Signalling Pathway Via PKC And MAPK 645295!!Metabolic Disorders Of Biological Oxidation Enzymes Pathway 1127637!!Peptide Ligand-binding Receptors Pathway 106358!!Signal Transduction Pathway 477114
ncbi summary :
This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues. [provided by RefSeq, Mar 2012]
size :
0.1 mg
price :
310 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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