MAT2A, 1-395aa, Human, His tag, Recombinant, E Coli | MyBioSource MBS203240 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

MAT2A, 1-395aa, Human, His tag, Recombinant, E Coli

catalog :

MBS203240

quantity :

0.1 mg

price :

310 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS203240

products type :

Recombinant Protein

products full name :

MAT2A, 1-395aa, Human, His tag, Recombinant, E Coli

products short name :

MAT2A

products name syn :

MATA2; MATII; SAMS2; Methionine adenosyltransferase II alpha; MAT2A; Methionine adenosyltransferase II; alpha AdoMet synthetase; AdoMet synthetase 2; AMS 2; MAT II; MATA 2; Methionine adenosyltransferase; Methionine adenosyltransferase 2; SAMS 2; Methionine adenosyltransferase II; S adenosylmethionine synthetase gamma form; S adenosylmethionine synthetase isoform type 2; S-adenosylmethionine synthetase isoform type 2

other names :

S-adenosylmethionine synthase isoform type-2; S-adenosylmethionine synthase isoform type-2; S-adenosylmethionine synthase isoform type-2; MAT 2; MAT-II; adoMet synthase 2; adoMet synthetase 2; methionine adenosyltransferase 2; methionine adenosyltransferase II, alpha; Methionine adenosyltransferase 2; MAT 2; Methionine adenosyltransferase II; MAT-II

products gene name :

MAT2A

other gene names :

MAT2A; MAT2A; MATA2; MATII; SAMS2; AMS2; MATA2; AdoMet synthase 2; MAT 2; MAT-II

uniprot entry name :

METK2_HUMAN

sequence length :

395

sequence :

MGSSHHHHHH SSGLVPRGSH MNGQLNGFHE AFIEEGTFLF TSESVGEGHP DKICDQISDA VLDAHLQQDP DAKVACETVA KTGMILLAGE ITSRAAVDYQ KVVREAVKHI GYDDSSKGFD YKTCNVLVAL EQQSPDIAQG VHLDRNEEDI GAGDQGLMFG YATDETEECM PLTIVLAHKL NAKLAELRRN GTLPWLRPDS KTQVTVQYMQ DRGAVLPIRV HTIVISVQHD EEVCLDEMRD ALKEKVIKAV VPAKYLDEDT IYHLQPSGRF VIGGPQGDAG LTGRKIIVDT YGGWGAHGGG AFSGKDYTKV DRSAAYAARW VAKSLVKGGL CRRVLVQVSY AIGVSHPLSI SIFHYGTSQK SERELLEIVK KNFDLRPGVI VRDLDLKKPI YQRTAAYGHF GRDSFPWEVP KKLKY

purity :

> 95% by SDS - PAGE

form :

Liquid in 20 mM Tris-HCl pH 8.0, 10% Glycerol

concentration :

1 mg/ml (determined by Bradford assay)

storage stability :

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

tested application :

SDS-PAGE

other info1 :

Antigen Species: Human. Tag: His-tag

other info2 :

Expression System: E Coli

products categories :

Cancer

products description :

Methionine adenosyltransferase II (MAT II) is a key enzyme in cellular metabolism and catalyzes the formation of S-adenosylmethionine (SAMe) from L-methionine and ATP. MAT2A is expressed in extrahepatic tissues. In liver, MAT2A expression associates with growth, dedifferentiation, and cancer. Recombinant MAT2A, fused to His-tag at N-terminus, was expressed in E.coli and purified by conventional chromatography techniques

products references :

Ramani K., et al. (2008). Hepatology. 47(2):521-31. Chen H.,. (2007) Gastroenterology. 133(1):207-18.

ncbi gi num :

5174529

ncbi acc num :

NP_005902

ncbi gb acc num :

NM_005911.5

ncbi mol weight :

45.8 kDa (415 aa), confirmed by MALDI-TOF.

ncbi pathways :

Biological Oxidations Pathway (105698); Biosynthesis Of Amino Acids Pathway (790012); Biosynthesis Of Amino Acids Pathway (795174); C-MYB Transcription Factor Network Pathway (138073); Cysteine And Methionine Metabolism Pathway (104488); Cysteine And Methionine Metabolism Pathway (103421); Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway (1127639); Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway (1127658); Defective GGT1 Causes Glutathionuria (GLUTH) Pathway (1127659); Defective GSS Causes Glutathione Synthetase Deficiency (GSS Deficiency) Pathway (1127660)

ncbi summary :

The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011]

uniprot summary :

MAT2A: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. Belongs to the AdoMet synthase family. Protein type: Amino Acid Metabolism - cysteine and methionine; Transferase; Other Amino Acids Metabolism - selenoamino acid; EC 2.5.1.6. Chromosomal Location of Human Ortholog: 2p11.2. Cellular Component: methionine adenosyltransferase complex; cytosol. Molecular Function: protein binding; methionine adenosyltransferase activity; metal ion binding; ATP binding. Biological Process: methylation; xenobiotic metabolic process; S-adenosylmethionine biosynthetic process; one-carbon compound metabolic process

size1 :

0.1 mg

price1 :

310 USD

size2 :

0.5 mg

price2 :

720

more info or order :

MyBioSource product webpage