LYVE1, 25-235aa, Human, His tag, Recombinant, Hi-5 cell | MyBioSource MBS203239 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

LYVE1, 25-235aa, Human, His tag, Recombinant, Hi-5 cell

catalog :

MBS203239

quantity :

0.05 mg

price :

510 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS203239

products type :

Recombinant Protein

products full name :

LYVE1, 25-235aa, Human, His tag, Recombinant, Hi-5 cell

products short name :

LYVE1

products name syn :

CRSBP-1; HAR; LYVE-1; XLKD1; Lymphatic vessel endothelial hyaluronan receptor 1; LYVE1; Lymphatic vessel endothelial hyaluronan receptor 1 CRSBP 1; CRSBP1; extracellular link domain containing 1; extracellular link domain-containing 1; hyaluronic acid receptor; LYVE 1; Lymphatic endothelium specific hyaluronan receptor.

other names :

lymphatic vessel endothelial hyaluronic acid receptor 1; Lymphatic vessel endothelial hyaluronic acid receptor 1; lymphatic vessel endothelial hyaluronic acid receptor 1; cell surface retention sequence binding protein-1; cell surface retention sequence-binding protein 1; extracellular link domain containing 1; extracellular link domain-containing 1; extracellular link domain-containing protein 1; lymphatic vessel endothelial hyaluronan receptor 1; Cell surface retention sequence-binding protein 1; CRSBP-1; Extracellular link domain-containing protein 1; Hyaluronic acid receptor

products gene name :

LYVE1

other gene names :

LYVE1; LYVE1; HAR; XLKD1; LYVE-1; CRSBP-1; CRSBP1; HAR; XLKD1; LYVE-1; CRSBP-1

uniprot entry name :

LYVE1_HUMAN

sequence length :

322

sequence :

ADPLRAEELS IQVSCRIMGI TLVSKKANQQ LNFTEAKEAC RLLGLSLAGK DQVETALKAS FETCSYGWVG DGFVVISRIS PNPKCGKNGV GVLIRKVPVS RQFAAYCYNS SDTWTNSCIP EIITTKDPIF NTQTATQTTE FIVSDSTYSV ASPYSTIPAP TTTPPAPAST SIPRRKKLIC VTEVFMETST MSTETEPFVE NKAAFKNEAA GFGGSGRLVP RGSHHHHHH

purity :

> 90% by SDS - PAGE

form :

Liquid in 20mM Tris pH7.5, 10% Glycerol

concentration :

1 mg/ml (determined by Bradford assay)

storage stability :

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

tested application :

SDS-PAGE

other info1 :

Antigen Species: Human. Tag: His-tag

other info2 :

Expression System: Hi-5

products categories :

Cancer

products description :

Lymphatic vascular endothelial hyaluronan receptor-1 (LYVE-1), a selective marker of the lymphatic endothelium, is a surface endocytic receptor for hyaluronan (HA), which is an extracellular glycosaminoglycan involved in cell adhesion and migration. LYVE1 is also known as XLKD1 and may function in lympathic hyaluronan transport and have a role in tumor metastasis. Recombinant human LYVE1 was expressed in High Five insect cells and purified by conventional chromatography techniques. As a result of glycosylation, the size of molecular weight will be shift-up as an approximately 50 kDa on SDS-PAGE analysis.

products references :

Chen L. et al. (2005) Invest. Ophthalmol Vis. Sci. 46, 4536-4540. Banerji S. et al. (1999) J. Cell Biol. 144, 789-801.

ncbi gi num :

40549451

ncbi acc num :

NP_006682

ncbi gb acc num :

NM_006691.3

ncbi mol weight :

24.8 kDa (229 aa), confirmed by MALDI-TOF.

ncbi pathways :

Defective B3GAT3 Causes JDSSDHD Pathway (1127588); Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway (1127592); Defective B4GALT7 Causes EDS, Progeroid Type Pathway (1127587); Defective CHST14 Causes EDS, Musculocontractural Type Pathway (1127591); Defective CHST3 Causes SEDCJD Pathway (1127590); Defective CHST6 Causes MCDC1 Pathway (1127593); Defective CHSY1 Causes TPBS Pathway (1127589); Defective EXT1 Causes Exostoses 1, TRPS2 And CHDS Pathway (1127594); Defective EXT2 Causes Exostoses 2 Pathway (1127595); Defective PAPSS2 Causes SEMD-PA Pathway (1127586)

ncbi summary :

This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. [provided by RefSeq, Jul 2008]

uniprot summary :

XLKD1: Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. Protein type: Motility/polarity/chemotaxis; Membrane protein, integral. Chromosomal Location of Human Ortholog: 11p15. Cellular Component: membrane; integral to plasma membrane; plasma membrane. Molecular Function: transmembrane receptor activity; hyaluronic acid binding; receptor activity. Biological Process: anatomical structure morphogenesis; glycosaminoglycan metabolic process; transport; cell-matrix adhesion; carbohydrate metabolic process; response to wounding; pathogenesis; cell motility; signal transduction; hyaluronan metabolic process; hyaluronan catabolic process

size1 :

0.05 mg

price1 :

510 USD

size2 :

0.25 mg

price2 :

1335

more info or order :

MyBioSource product webpage