BMP7 (monomer), 293-431aa, Human, His-tag, Recombinant, E Coli | MyBioSource MBS203230 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

BMP7 (monomer), 293-431aa, Human, His-tag, Recombinant, E Coli

catalog :

MBS203230

quantity :

0.1 mg

price :

255 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS203230

products type :

Recombinant Protein

products full name :

BMP7 (monomer), 293-431aa, Human, His-tag, Recombinant, E Coli

products short name :

BMP7

products name syn :

Osteogenic protein1; OP-1; Bone morphogenetic protein 7 BMP 7; Eptotermin alfa; OP 1; OP1.

other names :

bone morphogenetic protein 7; Bone morphogenetic protein 7; bone morphogenetic protein 7; osteogenic protein 1; bone morphogenetic protein 7; Osteogenic protein 1; OP-1; INN: Eptotermin alfa

products gene name :

BMP7

other gene names :

BMP7; BMP7; OP-1; OP1; BMP-7; OP-1

uniprot entry name :

BMP7_HUMAN

sequence length :

431

sequence :

MSTGSKQRSQ NRSKTPKNQE ALRMANVAEN SSSDQRQACK KHELYVSFRD LGWQDWIIAP EGYAAYYCEG ECAFPLNSYM NATNHAIVQT LVHFINPETV PKPCCAPTQL NAISVLYFDD SSNVILKKYR NMVVRACGCH LEHHHHHH

purity :

> 95% by SDS - PAGE

form :

Liquid. In 10mM Sodium Citrate buffer (pH 3.5) containing 10% glycerol

concentration :

0.5 mg/ml (determined by Bradford assay)

storage stability :

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

tested application :

SDS-PAGE

other info1 :

Antigen Species: Human. Tag: His-tag

other info2 :

Expression System: E Coli. Endotoxin: < 1.0 Eu per 1 microgram of protein (determined by LAL method)

products categories :

Hormones & Cytokines

products description :

Bone morphogenic protein-7 (BMP-7/OP-1) is a member of the transforming growth factor-beta (TGF-beta) superfamily. Like other members of the BMPs family, it plays a role in calcium regulation and bone homeostasis. BMPs have been also shown to regulate the growth, differentiation, chemotaxis and apoptosis of various cell types, including mesenchymal cells, epithelial cells, hematopoietic cells and neuronal cells. BMP7 also has the potential for treatment of chronic kidney disease. Recombinant human BMP-7 protein was expressed in E.coli and purified by using conventional chromatography techniques, after refolding of the isolated inclusion body in renaturation buffer.

products references :

Gonzalez EA., et al. (2002) Kidney Int. 61(4): 1322-31. Tseng YH., et al. (2008) Nature. 454(7207): 1000-4.

ncbi gi num :

4502427

ncbi acc num :

NP_001710

ncbi gb acc num :

NM_001719.2

ncbi mol weight :

16.8 kDa (148 aa), confirmed by MALDI-TOF.

ncbi pathways :

ALK2 Signaling Events Pathway (137983); BMP Receptor Signaling Pathway (137948); BMP Signaling Pathway (1084755); BMP Signaling Pathway (1108218); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Elastic Fibre Formation Pathway (730310); Endochondral Ossification Pathway (198812); Extracellular Matrix Organization Pathway (576262); Hippo Signaling Pathway (749777)

ncbi summary :

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development and possible bone inductive activity. [provided by RefSeq, Jul 2008]

uniprot summary :

BMP7: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1. Expressed in the kidney and bladder. Lower levels seen in the brain. Belongs to the TGF-beta family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 20q13. Cellular Component: extracellular matrix; extracellular space; extracellular region. Molecular Function: heparin binding; protein binding; growth factor activity; cytokine activity; transforming growth factor beta receptor binding. Biological Process: response to peptide hormone stimulus; negative regulation of MAP kinase activity; axon guidance; extracellular matrix organization and biogenesis; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; negative regulation of NF-kappaB import into nucleus; embryonic pattern specification; response to estradiol stimulus; negative regulation of cell cycle; BMP signaling pathway; regulation of apoptosis; response to vitamin D; epithelial cell differentiation; ureteric bud development; dendrite development; mesonephros development; skeletal development; embryonic limb morphogenesis; ossification; positive regulation of heterotypic cell-cell adhesion; positive regulation of bone mineralization; odontogenesis of dentine-containing teeth; positive regulation of osteoblast differentiation; negative regulation of neuron differentiation; mesenchymal cell differentiation; branching morphogenesis of a tube; mesoderm formation; inhibition of NF-kappaB transcription factor; cartilage development; negative regulation of mitosis; epithelial to mesenchymal transition; negative regulation of Notch signaling pathway; negative regulation of phosphorylation; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; embryonic camera-type eye morphogenesis; negative regulation of transcription, DNA-dependent; metanephros development; neurite morphogenesis; growth

size1 :

0.1 mg

price1 :

255 USD

size2 :

0.5 mg

price2 :

535

more info or order :

MyBioSource product webpage