FABP4, 1-132aa, Human, Recombinant, E Coli | MyBioSource MBS203220 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

FABP4, 1-132aa, Human, Recombinant, E Coli

catalog :

MBS203220

quantity :

0.1 mg

price :

375 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS203220

products type :

Recombinant Protein

products full name :

FABP4, 1-132aa, Human, Recombinant, E Coli

products short name :

FABP4

products name syn :

IL-1 alpha; Hematopoietin-1; Fatty acid binding protein 4; Fatty acid-binding protein; adipocyte; A-FABP; ALBP; FABP4; fatty acid binding protein 4 adipocyte; aP2

other names :

interleukin-1 alpha proprotein; Interleukin-1 alpha; interleukin-1 alpha; IL-1 alpha; hematopoietin-1; preinterleukin 1 alpha; pro-interleukin-1-alpha; interleukin 1, alpha; Hematopoietin-1

products gene name :

FABP4

other gene names :

IL1A; IL1A; IL1; IL-1A; IL1F1; IL1-ALPHA; IL1F1; IL-1 alpha

uniprot entry name :

IL1A_HUMAN

sequence length :

271

sequence :

MCDAFVGTWK LVSSENFDDY MKEVGVGFAT RKVAGMAKPN MIISVNGDVI TIKSESTFKN TEISFILGQE FDEVTADDRK VKSTITLDGG VLVHVQKWDG KSTTIKRKRE DDKLVVECVM KGVTSTRVYE RA

purity :

> 95% by SDS - PAGE

form :

Liquid in 20mM Tris-HCl pH 7.5, 10% glycerol

concentration :

1 mg/ml (determined by Bradford assay)

storage stability :

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

tested application :

SDS-PAGE

other info1 :

Antigen Species: Human

other info2 :

Expression System: E Coli. Endotoxin: < 1.0 Eu per 1 microgram of protein (determined by LAL method)

products categories :

Hormones & Cytokines

products description :

IL-1 consists of two distinct forms, IL-1 alpha and IL-1 beta which perform the same functions but are distinct proteins. IL-1alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is also temporarily upregulated during bone formation and the menstrual cycle and can be induced in response to nervous system stimulation. Recombinant IL-1a protein was expressed in E.coli and purified by using conventional chromatography techniques

products references :

Furuhashi M., et al. (2007).Nature. 447(7147):959-65. Shum BO., et al. (2006).J Clin Invest. 116(8):2183-2192.

ncbi gi num :

27894330

ncbi acc num :

NP_000566

ncbi gb acc num :

NM_000575.3

ncbi mol weight :

14kDa (132aa), confirmed by MALDI-TOF.

ncbi pathways :

Apoptosis Pathway (83060); Apoptosis Pathway (470); Cellular Senescence Pathway (905991); Cellular Responses To Stress Pathway (645258); Cytokine Signaling In Immune System Pathway (366171); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Cytokines And Inflammatory Response Pathway (198794); FAS Pathway And Stress Induction Of HSP Regulation (198894); Graft-versus-host Disease Pathway (83124)

ncbi summary :

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008]

uniprot summary :

IL1A: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. Belongs to the IL-1 family. Protein type: Motility/polarity/chemotaxis; Cytokine. Chromosomal Location of Human Ortholog: 2q14. Cellular Component: extracellular space; extracellular region; cytosol. Molecular Function: protein binding; interleukin-1 receptor binding; copper ion binding; cytokine activity. Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of mitosis; apoptosis; positive regulation of interleukin-2 biosynthetic process; cytokine and chemokine mediated signaling pathway; germ cell programmed cell death; positive regulation of JNK cascade; fever; cell proliferation; negative regulation of cell proliferation; positive regulation of angiogenesis; connective tissue replacement during inflammatory response; response to copper ion; positive regulation of transcription from RNA polymerase II promoter; immune response; inflammatory response; positive regulation of cytokine secretion

size1 :

0.1 mg

price1 :

375 USD

size2 :

0.5 mg

price2 :

925

more info or order :

MyBioSource product webpage