protein

BNP, 27-134aa, Human, His-tag, Recombinant, E Coli

MBS203219

0.1 mg

310 USD

Recombinant Protein

BNP, 27-134aa, Human, His-tag, Recombinant, E Coli

BNP

NPPB; GC-B; Brain natriuretic peptide (type B natriuretic peptide); BNP; Brain natriuretic peptide (type B natriuretic peptide) Gamma brain natriuretic peptide; Natriuretic peptide precursor B; Natriuretic peptides B

natriuretic peptides B preproprotein; Natriuretic peptides B; natriuretic peptides B; brain type natriuretic peptide; gamma-brain natriuretic peptide; natriuretic peptide precursor B; natriuretic protein; natriuretic peptide B; Gamma-brain natriuretic peptideCleaved into the following 16 chains:Brain natriuretic peptide 32; BNP(1-32); BNP-32; BNP(1-30); BNP(1-29); BNP(1-28); BNP(2-31); BNP(3-32); BNP(3-30); BNP(3-29); BNP(4-32); BNP(4-31); BNP(4-30); BNP(4-29); BNP(4-27); BNP(5-32); BNP(5-31); BNP(5-29)

BNP

NPPB; NPPB; BNP; BNP(1-32); BNP-32

ANFB_HUMAN

134

MGSSHHHHHH SSGLVPRGSH MHPLGSPGSA SDLETSGLQE QRNHLQGKLS ELQVEQTSLE PLQESPRPTG VWKSREVATE GIRGHRKMVL YTLRAPRSPK MVQGSGCFGR KMDRISSSSG LGCKVLRRH

> 90% by SDS - PAGE

Liquid in Phosphate-Buffered Saline (pH 7.4), 40%glycerol, 2mM DTT, 0.1mM PMSF, 1mM EDTA

0.5 mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human. Tag: His-tag

Expression System: E Coli. Endotoxin: < 1.0 Eu per 1 microgram of protein (determined by LAL method)

Hormones & Cytokines

BNP (Brain natriuretic peptide) is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. BNP is a 32 amino acid polypeptide and is co-secreted along with a 76 amino acid N-terminal fragment which is biologically inactive. This protein has biological actions including natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion. It is thought to play a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Recombinant human BNP, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Harada H., et al. (1989) Cell. 58(4):729-739 . Matsuyama T., et al. (1993) Cell 75(1):83-97.

4505433

NP_002512

NM_002521.2

14 kDa (129 aa), confirmed by MALDI-TOF.

MicroRNAs In Cardiomyocyte Hypertrophy Pathway 198784!!CGMP-PKG Signaling Pathway 983748!!CGMP-PKG Signaling Pathway 985584

This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Nov 2014]

0.1 mg

310 USD