protein

C1QBP,74-282aa, Human, Recombinant, E Coli

MBS203217

0.1 mg

310 USD

Recombinant Protein

C1QBP,74-282aa, Human, Recombinant, E Coli

C1QBP

p33; HABP1; gC1qR; GC1QBP; SF2p32; Complement component 1 q subcomponent binding protein; C1QBP; Complement component 1; q subcomponent binding protein C1q globular domain binding protein; Complement component 1 Q subcomponent binding protein mitochondrial; GC1Q R; GC1q R protein; GC1QR; Glycoprotein gC1qBP; HABP 1; Hyaluronan binding protein 1; Mitochondrial matrix protein p32; p32; Pre mrna splicing factor SF2 P32 subunit precursor; Splicing factor SF2 associated protein.

complement component 1 Q subcomponent-binding protein, mitochondrial; Complement component 1 Q subcomponent-binding protein, mitochondrial; complement component 1 Q subcomponent-binding protein, mitochondrial; ASF/SF2-associated protein p32; C1q globular domain-binding protein; glycoprotein gC1qBP; hyaluronan-binding protein 1; mitochondrial matrix protein p32; p33; splicing factor SF2-associated protein; complement component 1, q subcomponent binding protein; ASF/SF2-associated protein p32; Glycoprotein gC1qBP; C1qBP; Hyaluronan-binding protein 1; Mitochondrial matrix protein p32; gC1q-R protein; p33

C1QBP

C1QBP; C1QBP; p32; HABP1; gC1qR; GC1QBP; SF2p32; gC1Q-R; GC1QBP; HABP1; SF2P32; C1qBP

C1QBP_HUMAN

282

MLHTDGDKAF VDFLSDEIKE ERKIQKHKTL PKMSGGWELE LNGTEAKLVR KVAGEKITVT FNINNSIPPT FDGEEEPSQG QKVEEQEPEL TSTPNFVVEV IKNDDGKKAL VLDCHYPEDE VGQEDEAESD IFSIREVSFQ STGESEWKDT NYTLNTDSLD WALYDHLMDF LADRGVDNTF ADELVELSTA LEHQEYITFL EDLKSFVKSQ

> 95% by SDS - PAGE

Liquid in 20 mM Tris pH 7.5, 1 mM DTT, 20% Glycerol.

1 mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human

Expression System: E Coli. Endotoxin: < 1.0 Eu per 1 ug of protein (determined by LAL method)

Hormones & Cytokines

Human complement component 1, q subcomponent binding protein (C1QBP) is a ubiquitously expressed multifunctional phospho-protein that interacts with the globular heads of C1q (gC1q). This protein also interacts with a wide range of ligands and is implicated in cell signaling. General references : Recombinant C1QBP was expressed in E.coli and purified by conventional chromatography techniques.

Fogal V., et al (2008) Cancer Res. 68(17):7210-8. Biswas AK., et al (2007) PLoS Pathog. 3(9):1271-80.

4502491

NP_001203

NM_001212.3

23.9kDa (210aa), confirmed by MALDI-TOF.

Formation Of Fibrin Clot (Clotting Cascade) Pathway (106057); Hemostasis Pathway (106028); Herpes Simplex Infection Pathway (377873); Herpes Simplex Infection Pathway (377865); Intrinsic Pathway (106059)

The human complement subcomponent C1q associates with C1r and C1s in order to yield the first component of the serum complement system. The protein encoded by this gene is known to bind to the globular heads of C1q molecules and inhibit C1 activation. This protein has also been identified as the p32 subunit of pre-mRNA splicing factor SF2, as well as a hyaluronic acid-binding protein. [provided by RefSeq, Jul 2008]

C1QBP: a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. Originally identified via its binding interactions with Splicing Factor (SF-2). Multiple, diverse binding partners of C1QBP were subsequently identified, including the globular heads of complement component C1q, hyaluronic acid, selected protein kinases, the tumor suppressor ARF, and multiple antigens of bacterial and viral origin. Overexpressed in a number of cancer cell types, and has been implicated in the Warburg effect, whereby cancer cells shift their metabolism from oxidative phosphorylation to glycolysis. Inhibits the Mitochondrial Permeability Transition (MPT) pore, possibly serving a protective function against damage from oxidative stress. Binding to C1q inhibits C1. In complex with cytokeratin-1/KRT1 is a high affinty receptor for kininogen-1/HMWK. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. The cell surface form may require docking with transmembrane proteins for downstream signaling which might be specific for a cell-type or response. Belongs to the MAM33 family. Protein type: Motility/polarity/chemotaxis; Nucleolus; Receptor, misc.; Mitochondrial. Chromosomal Location of Human Ortholog: 17p13.3. Cellular Component: extracellular space; cell surface; mitochondrion; membrane; mitochondrial matrix; cytoplasm; nucleolus; plasma membrane; cytosol; nucleus. Molecular Function: mRNA binding; protein binding; adrenergic receptor binding; protein kinase C binding; complement component C1q binding; hyaluronic acid binding; kininogen binding; transcription corepressor activity; transcription factor binding. Biological Process: negative regulation of interleukin-12 production; phosphoinositide 3-kinase cascade; positive regulation of cell adhesion; transcription, DNA-dependent; viral reproduction; positive regulation of apoptosis; apoptosis; RNA splicing; negative regulation of transcription from RNA polymerase II promoter; negative regulation of defense response to virus; positive regulation of protein kinase B signaling cascade; negative regulation of nuclear mRNA splicing, via spliceosome; negative regulation of interferon-gamma production; regulation of complement activation; innate immune response; immune response; mRNA processing; blood coagulation; blood coagulation, intrinsic pathway; complement activation, classical pathway; mature ribosome assembly

0.1 mg

310 USD

0.5 mg

720