catalog number :
MBS2032166
products full name :
Thromboxane Receptor (TP) Polyclonal Antibody
products short name :
[Thromboxane Receptor]
products name syn :
[TBXA2R; TXA2-R; Thromboxane A2 Receptor; Prostanoid TP receptor]
other names :
[thromboxane A2 receptor isoform alpha; Thromboxane A2 receptor; thromboxane A2 receptor; thromboxane A2 receptor; Prostanoid TP receptor]
products gene name :
[TP]
other gene names :
[TBXA2R; TBXA2R; TXA2-R; BDPLT13; TXA2-R]
purity :
Antigen-specific affinity chromatography followed by Protein A affinity chromatography.
form :
Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
concentration :
0.52mg/ml
storage stability :
Storage: Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the
expiration date under appropriate storage condition.
tested application :
WB; IHC; ICC; IP.
app notes :
Western blotting: 0.5-2(Ug/mL;1:250-1000. Immunohistochemistry: 5-20(Ug/mL;1:25-100. Immunocytochemistry: 5-20(Ug/mL;1:25-100.
Optimal working dilutions must be determined by end user.
image1 heading :
Western Blot (WB)
image2 heading :
Western Blot (WB)
image3 heading :
Immunohistochemistry (IHC)
other info1 :
Organism Species: Homo sapiens (Human). Source: Polyclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant Thromboxane Receptor (Pro3~Ser324) expressed in E.coli
other info2 :
Conjugated Antibody: The APC-Cy7 conjugated antibody version of this item is also available as catalog #MBS2068372
ncbi acc num :
NP_001051.1
ncbi gb acc num :
NM_001060.5
ncbi pathways :
Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Eicosanoid Ligand-binding Receptors Pathway (106370); G Alpha (12/13) Signalling Events Pathway (106041); G Alpha (q) Signalling Events Pathway (106043); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886); Gastrin-CREB Signalling Pathway Via PKC And MAPK (645295)
ncbi summary :
This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
uniprot summary :
Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.