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company name :
MyBioSource
product type :
protein
product name :
uBE2L6, 1-152aa, Human, His tag, Recombinant, E Coli
catalog :
MBS203212
quantity :
0.1 mg
price :
375 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS203212
products type :
Recombinant Protein
products full name :
uBE2L6, 1-152aa, Human, His tag, Recombinant, E Coli
products short name :
uBE2L6
products name syn :
uBCH8; RIG-B; ubiquitin conjugating enzyme E2L 6; uBE2L6; ubiquitin conjugating enzyme E2L 6 MGC40331; Retinoic acid induced gene B protein; RIG B; uBCH 8; ubiquitin carrier protein; ubiquitin carrier protein L6; ubiquitin protein ligase; ubiquitin protein ligase L6; ubiquitin/ISG15 conjugating enzyme E2 L6.
other names :
ubiquitin/ISG15-conjugating enzyme E2 L6 isoform 1; Ubiquitin/ISG15-conjugating enzyme E2 L6; ubiquitin/ISG15-conjugating enzyme E2 L6; retinoic acid induced gene B protein; retinoic acid-induced gene B protein; ubiquitin carrier protein L6; ubiquitin-protein ligase L6; ubiquitin-conjugating enzyme E2L 6; Retinoic acid-induced gene B protein; RIG-B; UbcH8; Ubiquitin carrier protein L6; Ubiquitin-protein ligase L6
products gene name :
uBE2L6
other gene names :
UBE2L6; UBE2L6; RIG-B; UBCH8; UBCH8; RIG-B
uniprot entry name :
UB2L6_HUMAN
sequence length :
153
sequence :
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMASM RVVKELEDLQ KKPPPYLRNL SSDDANVLVW HALLLPDQPP YHLKAFNLRI SFPPEYPFKP PMIKFTTKIY HPNVDENGQI CLPIISSENW KPCTKTCQVL EALNVLVNRP NIREPLRMDL ADLLTQNPEL FRKNAEEFTL RFGVDRPS
purity :
> 90% by SDS PAGE
form :
Liquid in 20mM Tris pH 8.0, 1mM DTT, 0.1mM PMSF, 10% glycerol
concentration :
1 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human. Tag: His-tag
other info2 :
Expression System: E Coli
products categories :
ubiquitination
products description :
ubiquitin-conjugating enzyme E2L6 (uBE2L6), also known as ubcH8, is a member of the E2 ubiquitin-conjugating enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. ubiquitination of a protein substrate requires the concerted action of 3 classes of enzymes: E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin protein ligases. The E2 ubiquitin-conjugating enzyme is highly similar in primary structure to the enzyme encoded by uBE2L3 gene. Recombinant human uBE2L6 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
products references :
Ardley HC., et al. (2000) Cytogenet Cell Genet. 89(1-2):137-140. Movnihan TP., et al. (1999) J Biol Chem. 274(43):30963-30968.
ncbi gi num :
4759282
ncbi acc num :
NP_004214
ncbi gb acc num :
NM_004223.4
ncbi mol weight :
21.7kDa (188aa), confirmed by MALDI-TOF.
ncbi pathways :
Adaptive Immune System Pathway 366160!!Antigen Processing: Ubiquitination Proteasome Degradation Pathway 366162!!Antiviral Mechanism By IFN-stimulated Genes Pathway 530760!!Class I MHC Mediated Antigen Processing Presentation Pathway 366161!!Cytokine Signaling In Immune System Pathway 366171!!ISG15 Antiviral Mechanism Pathway 530761!!Immune System Pathway 106386!!Innate Immune System Pathway 106387!!Interferon Signaling Pathway 187103!!Negative Regulators Of RIG-I/MDA5 Signaling Pathway 187102
ncbi summary :
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2011]
size :
0.1 mg
price :
375 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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