Stathmin, 1-149aa, Human, His-tag, Recombinant, E Coli | MyBioSource MBS203211 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Stathmin, 1-149aa, Human, His-tag, Recombinant, E Coli

catalog :

MBS203211

quantity :

0.1 mg

price :

310 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS203211

products type :

Recombinant Protein

products full name :

Stathmin, 1-149aa, Human, His-tag, Recombinant, E Coli

products short name :

Stathmin

products name syn :

STMN1; Phosphoprotein p19 (pp19); Oncoprotein 18(Op18); pp17; Prosolin; Metablastin; LAP18; Lag; LAP 18; Leukemia associated phosphoprotein p18; Metablastin; Oncoprotein 18; OP 18; OP18; p18; p19; Phosphoprotein 19; Phosphoprotein p19; PP19; PR22; Pr22 protein; Prosolin; Protein Pr22; SMN; Stathmin; Stathmin1; STMN 1.

other names :

stathmin isoform a; Stathmin; stathmin; leukemia-associated phosphoprotein p18; metablastin; oncoprotein 18; phosphoprotein 19; phosphoprotein p19; prosolin; stathmin 1/oncoprotein 18; transmembrane protein C1orf215; stathmin 1; Leukemia-associated phosphoprotein p18; Metablastin; Oncoprotein 18; Op18; Phosphoprotein p19; pp19; Prosolin; Protein Pr22; pp17

other gene names :

STMN1; STMN1; Lag; SMN; OP18; PP17; PP19; PR22; LAP18; C1orf215; C1orf215; LAP18; OP18; Op18; pp19

uniprot entry name :

STMN1_HUMAN

sequence length :

149

sequence :

MGSSHHHHHH SSGLVPRGSH MASSDIQVKE LEKRASGQAF ELILSPRSKE SVPEFPLSPP KKKDLSLEEI QKKLEAAEER RKSHEAEVLK QLAEKREHEK EVLQKAIEEN NNFSKMAEEK LTHKMEANKE NREAQMAAKL ERLREKDKHI EEVRKNKESK DPADETEAD

purity :

> 95% by SDS - PAGE

form :

Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

concentration :

1 mg/ml (determined by Bradford assay)

storage stability :

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

tested application :

SDS-PAGE

other info1 :

Antigen Species: Human. Tag: His-tag

other info2 :

Expression System: E Coli

products categories :

Cell Cycle

products description :

Stathmin is a ubiquitous phosphoprotein proposed to play a general role as an intracellular relay integrating diverse regulatory signals of the cellular environment. Also, Stathmin protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. The role of Stathmin in regulation of the cell cycle causes it to be an oncoprotein (Oncoprotein 18, op18). When Stathmin is mutated and not functioning properly, this protein can cause uncontrolled cell proliferation. Recombinant human Stathmin protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

products references :

Maucuer A., et al. (1990). FEBS Lett. 264(2):275-8. Sobel A., et al. (1991). Trends Biochem Sci. 16(8):301-5 . Steinmetz MO., et al. (2007). J Struct Biol. 158(2):137-47.

ncbi gi num :

44890050

ncbi acc num :

NP_981944

ncbi gb acc num :

NM_203399.1

ncbi mol weight :

19.4 kDa (169aa), confirmed by MALDI-TOF.

ncbi pathways :

Aurora B Signaling Pathway (138080); Integrated Pancreatic Cancer Pathway (711360); MAPK Signaling Pathway (198779); MAPK Signaling Pathway (83048); MAPK Signaling Pathway (456); MicroRNAs In Cancer Pathway (852705); MicroRNAs In Cancer Pathway (852928); RB In Cancer Pathway (920977); Regulation Of Microtubule Cytoskeleton Pathway (755439); Signaling Mediated By P38-gamma And P38-delta Pathway (138043)

ncbi summary :

This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

uniprot summary :

STMN1: a microtubule-associated protein involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Phosphorylation reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, nonleukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia. Protein type: Cytoskeletal. Chromosomal Location of Human Ortholog: 1p36.11. Cellular Component: microtubule; neuron projection; membrane; cytoplasm; intracellular; cytosol. Molecular Function: tubulin binding; signal transducer activity. Biological Process: mitotic spindle organization and biogenesis; axonogenesis; response to virus; negative regulation of microtubule polymerization; microtubule depolymerization; positive regulation of cell motility; brain development; signal transduction; neurite development; regulation of cytoskeleton organization and biogenesis

size1 :

0.1 mg

price1 :

310 USD

size2 :

0.5 mg

price2 :

720

more info or order :

MyBioSource product webpage