Myostatin (MSTN) Monoclonal Antibody | MyBioSource MBS2032052 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Myostatin (MSTN) Monoclonal Antibody

catalog :

MBS2032052

quantity :

0.01 mg

price :

105 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[A4]

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot: Sample: Human Liver Tissue.

image 2 :

Western Blot: Sample: Recombinant MSTN, Human.

image 3 :

DAB staining on IHC-P; Samples: Human Pancreas Cancer Tissue.

product information

catalog number :

MBS2032052

products type :

Antibody

products full name :

Myostatin (MSTN) Monoclonal Antibody

products short name :

[Myostatin]

products name syn :

[GDF8; Growth Differentiation Factor 8]

other names :

[growth/differentiation factor 8 preproprotein; Growth/differentiation factor 8; growth/differentiation factor 8; myostatin; Myostatin]

products gene name :

[MSTN]

other gene names :

[MSTN; MSTN; GDF8; MSLHP; GDF8; GDF-8]

clonality :

Monoclonal

isotype :

IgG2a Kappa

clone :

[A4]

host :

Mouse

purity :

Protein A + Protein G affinity chromatography

form :

Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.

concentration :

1 mg/ml

storage stability :

Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

Western Blot (WB), Immunohistochemestry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)

app notes :

Western blotting: 0.5-2 ug/mL;1:500-2000. Immunohistochemistry: 5-20 ug/mL;1:50-200. Immunocytochemistry: 5-20 ug/mL;1:50-200. Optimal working dilutions must be determined by end user.

image1 heading :

Western Blot (WB)

image2 heading :

Western Blot (WB)

image3 heading :

Immunohistochemistry (IHC)

image4 heading :

Immunohistochemistry (IHC)

image4 description :

DAB staining on IHC-P; Samples: Human Liver Tissue

image5 heading :

Immunohistochemistry (IHC)

image5 description :

DAB staining on IHC-P; Samples: Human Kidney Tissue.

other info1 :

Source: Monoclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant MSTN (Asp267~Ser375) expressed in E.coli

ncbi gi num :

4885259

ncbi acc num :

NP_005250.1

ncbi gb acc num :

NM_005259.2

uniprot acc num :

O14793

ncbi pathways :

Hypertrophy Model Pathway (198828)

ncbi summary :

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals. [provided by RefSeq, Jul 2016]

uniprot summary :

MSTN: Acts specifically as a negative regulator of skeletal muscle growth. Defects in MSTN are the cause of muscle hypertrophy (MSLHP). MSLHP is a condition characterized by increased muscle bulk and strength. Affected individuals are exceptionally strong. Belongs to the TGF-beta family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 2q32.2. Cellular Component: cytoplasm; extracellular space. Molecular Function: cytokine activity; growth factor activity; heparin binding; identical protein binding; protein binding; protein homodimerization activity; receptor binding; transforming growth factor beta receptor binding. Biological Process: cell development; muscle maintenance; muscle organ development; negative regulation of insulin receptor signaling pathway; negative regulation of kinase activity; negative regulation of muscle hypertrophy; negative regulation of myoblast differentiation; negative regulation of protein kinase B signaling cascade; negative regulation of skeletal muscle tissue growth; ovulation cycle process; positive regulation of transcription, DNA-templated; regulation of apoptosis; regulation of MAPK cascade; response to electrical stimulus; response to estrogen; response to ethanol; response to gravity; response to heat; response to muscle activity; response to testosterone stimulus; skeletal muscle atrophy; skeletal muscle tissue regeneration; transforming growth factor beta receptor signaling pathway. Disease: Muscle Hypertrophy

size1 :

0.01 mg

price1 :

105 USD

size2 :

0.02 mg

price2 :

110

size3 :

0.05 mg

price3 :

145

size4 :

0.1 mg

price4 :

175

size5 :

0.2 mg

price5 :

230

size6 :

1 mg

price6 :

515

more info or order :

MyBioSource product webpage