protein

GADD45B, 1-160aa, Human, Recombinant, E Coli

MBS203204

0.1 mg

255 USD

Recombinant Protein

GADD45B, 1-160aa, Human, Recombinant, E Coli

GADD45B

MYD118; Growth arrest and DNA-damage-inducible beta; GADD45B; Growth arrest and DNA-damage-inducible; beta GADD45 Beta; GADD45BETA; ADD45 beta; growth arrest and DNA-damage-inducible 45 beta; Growth arrest and DNA-damage-inducible protein; myeloid differentiation primary response gene; Myeloid differentiation primary response protein MyD118; Negative growth-regulatory protein MyD118.

growth arrest and DNA damage-inducible protein GADD45 beta; Growth arrest and DNA damage-inducible protein GADD45 beta; growth arrest and DNA damage-inducible protein GADD45 beta; myeloid differentiation primary response protein MyD118; negative growth regulatory protein MyD118; growth arrest and DNA-damage-inducible, beta; Myeloid differentiation primary response protein MyD118; Negative growth regulatory protein MyD118

GADD45B

GADD45B; GADD45B; MYD118; GADD45BETA; MYD118

GA45B_HUMAN

160

MTLEELVACD NAAQKMQTVT AAVEELLVAA QRQDRLTVGV YESAKLMNVD PDSVVLCLLA IDEEEEDDIA LQIHFTLIQS FCCDNDINIV RVSGMQRLAQ LLGEPAETQG TTEARDLHCL LVTNPHTDAW KSHGLVEVAS YCEESRGNNQ WVPYISLQER

> 95% by SDS-PAGE

Liquid. In 20 mM Tris-HCl buffer (pH 7.5)

1 mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human

Expression System: E Coli

Cell Cycle

GADD45B is a member of GADD45 family (GADD45alpha, beta, and gamma) that are nuclear proteins to interact with various proteins implicated in stress responses and cell-cycle-related proteins. The function of GADD45 proteins is involved in growth-regulatory mechanisms and apoptosis. GADD45B is necessary for adult neurogenesis, including brain-derived neurotrophic factor and fibroblast growth factor. And therefore, this protein is implicated in affecting synaptic plasticity. Recombinant GADD45B protein was expressed in E.coli and purified by using conventional chromatography techniques.

Takekawa M., et al. (1998) Cell 95(4), 521-30. Zerbini LF., et al. (2004) PNAS 101(37), 13618-23.

86991436

NP_056490

NM_015675.3

17.8 kDa (160 aa), confirmed by MALDI-TOF.

Adipogenesis Pathway 198832!!Cell Cycle Pathway 83054!!Cell Cycle Pathway 463!!DNA Damage Response Pathway 198788!!FoxO Signaling Pathway 921162!!IL12-mediated Signaling Events Pathway 137922!!MAPK Signaling Pathway 83048!!MAPK Signaling Pathway 456!!NF-kappa B Signaling Pathway 634527!!P38 MAPK Signaling Pathway 137943

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]

0.1 mg

255 USD