protein

FABP6, isoform2, 1-128aa, Human, Recombinant, E Coli

MBS203200

0.1 mg

375 USD

Recombinant Protein

FABP6, isoform2, 1-128aa, Human, Recombinant, E Coli

FABP6

I-BABP; I-15P; ILLBP; ILBP; ILBP3; I-BAP; I-BALB; Fatty acid binding protein 6; Gastrotropin; FABP6; Fatty acid binding protein 6 Fatty acid binding protein 6; ileal (gastrotropin); GT; I 15P; I BABP; I BALB; I BAP; I15P; IBABP; IBALB; IBAP; ILBP; Ileal lipid binding protein; Intestinal 15 kDa protein; Intestinal bile acid binding protein.

FABP6 protein; Gastrotropin; gastrotropin; GT; ileal bile acid binding protein; ileal lipid-binding protein; illeal lipid-binding protein; intestinal 15 kDa protein; fatty acid binding protein 6, ileal; Fatty acid-binding protein 6; Ileal lipid-binding protein; ILBP; Intestinal 15 kDa protein; I-15P; Intestinal bile acid-binding protein; I-BABP

FABP6

FABP6; FABP6; ILBP; I-15P; I-BAP; ILBP3; ILLBP; I-BABP; I-BALB; ILBP; ILLBP; GT; ILBP; I-15P; I-BABP

FABP6_HUMAN

128

MAFTGKFEME SEKNYDEFMK LLGISSDVIE KAHNFKIVTE VQQDGQDFTW SQHYYGGHTM TNKFTVGKES NIQTMGGKTF KATVQMEGGK LVVNFPNYHQ TSEIVGDKLV EVSTIGGVTY ERVSKRLA

> 95% by SDS - PAGE

Liquid in Phosphate buffered saline (pH7.4), 10% glycerol

1 mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human

Expression System: E Coli

Cell Cycle

FABP-6 is a cytosolic protein that binds bile acids with a high affinity. In the small intestine, its expression is restricted to the ileum where it is involved in the enterohepatic circulation of bile acids. Alternate transcription promoters generate two transcript variants, encoding a 128 aa and a 177 aa residue protein. Human FABP6 isoform 2 contains 128 amino acid residues and is believed to be acetylated on Ala2. It binds both fatty acids and bile acids and has roles in fatty acid transport and metabolism. Recombinant human FABP-6 was expressed in E.coli and purified by using conventional chromatography techniques.

Ohmachi T., et al. (2006). Clin Cancer Res. Sep 1; 12(17):5090-5. Grober J., et al. (1999) J Biol Chem. Oct 15; 274(42):29749-54.

18490679

AAH22489

14kDa (128aa), confirmed by MALDI-TOF.

Bile Acid And Bile Salt Metabolism Pathway (106144); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); Orphan Transporters Pathway (1127546); PPAR Signaling Pathway (83042); PPAR Signaling Pathway (450); Recycling Of Bile Acids And Salts Pathway (106149); Transmembrane Transport Of Small Molecules Pathway (106572)

This gene encodes the ileal fatty acid binding protein. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP6 and FABP1 (the liver fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. Transcript variants generated by alternate transcription promoters and/or alternate splicing have been found for this gene. [provided by RefSeq, Jul 2008]

FABP6: Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. 2 isoforms of the human protein are produced by alternative promoter. Protein type: Lipid-binding. Chromosomal Location of Human Ortholog: 5q33.3-q34. Cellular Component: cytoplasm; cytosol. Molecular Function: transporter activity; lipid binding. Biological Process: bile acid and bile salt transport; negative regulation of cell proliferation; bile acid metabolic process; lipid metabolic process; transmembrane transport

0.1 mg

375 USD

0.5 mg

925