HSPA9, 47-679aa, Human, His-tag, Recombinant, E Coli | MyBioSource MBS203188 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

HSPA9, 47-679aa, Human, His-tag, Recombinant, E Coli

catalog :

MBS203188

quantity :

0.1 mg

price :

255 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS203188

products type :

Recombinant Protein

products full name :

HSPA9, 47-679aa, Human, His-tag, Recombinant, E Coli

products short name :

HSPA9

products name syn :

Mortalin; GRP75; mot-2; HSPA9B; PBP74; CSA; HSPA9; Heat shock 70kDa protein 9; Heat shock 70kDa protein 9; heat shock 70kDa protein 9 (mortalin); heat shock 70kDa protein 9B (mortalin-2); mthsp75

other names :

stress-70 protein, mitochondrial; Stress-70 protein, mitochondrial; stress-70 protein, mitochondrial; 75 kDa glucose-regulated protein; catecholamine-regulated protein 40; epididymis secretory sperm binding protein Li 124m; heat shock 70kD protein 9B; mortalin, perinuclear; mortalin-2; p66-mortalin; peptide-binding protein 74; heat shock 70kDa protein 9 (mortalin); 75 kDa glucose-regulated protein; GRP-75; Heat shock 70 kDa protein 9; Mortalin; MOT; Peptide-binding protein 74; PBP74

products gene name :

HSPA9

other gene names :

HSPA9; HSPA9; CSA; MOT; MOT2; CRP40; GRP75; PBP74; GRP-75; HSPA9B; MTHSP75; HEL-S-124m; GRP75; HSPA9B; mt-HSP70; GRP-75; MOT; PBP74

uniprot entry name :

GRP75_HUMAN

sequence length :

679

sequence :

MGSSHHHHHH SSGLVPRGSH MASEAIKGAV VGIDLGTTNS CVAVMEGKQA KVLENAEGAR TTPSVVAFTA DGERLVGMPA KRQAVTNPNN TFYATKRLIG RRYDDPEVQK DIKNVPFKIV RASNGDAWVE AHGKLYSPSQ IGAFVLMKMK ETAENYLGHT AKNAVITVPA YFNDSQRQAT KDAGQISGLN VLRVINEPTA AALAYGLDKS EDKVIAVYDL GGGTFDISIL EIQKGVFEVK STNGDTFLGG EDFDQALLRH IVKEFKRETG VDLTKDNMAL QRVREAAEKA KCELSSSVQT DINLPYLTMD SSGPKHLNMK LTRAQFEGIV TDLIRRTIAP CQKAMQDAEV SKSDIGEVIL VGGMTRMPKV QQTVQDLFGR APSKAVNPDE AVAIGAAIQG GVLAGDVTDV LLLDVTPLSL GIETLGGVFT KLINRNTTIP TKKSQVFSTA ADGQTQVEIK VCQGEREMAG DNKLLGQFTL IGIPPAPRGV PQIEVTFDID ANGIVHVSAK DKGTGREQQI VIQSSGGLSK DDIENMVKNA EKYAEEDRRK KERVEAVNMA EGIIHDTETK MEEFKDQLPA DECNKLKEEI SKMRELLARK DSETGENIRQ AASSLQQASL KLFEMAYKKM ASEREGSGSS GTGEQKEDQK EEKQ

purity :

> 95% by SDS - PAGE

form :

Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 0.5mM DTT, 10% glycerol

concentration :

1 mg/ml (determined by Bradford assay)

storage stability :

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

tested application :

SDS-PAGE

other info1 :

Antigen Species: Human. Tag: His-tag

other info2 :

Expression System: E Coli

products categories :

Heat Shock Proteins

products description :

HSPA9 belongs to the heat shock protein 70 family which contains both heat-inducible and constitutively expressed members. HSPA9 was localized to chromosome 5, band q31, a region that is frequently deleted in myeloid leukemias and myelodysplasia (MDS), making it a candidate tumor suppressor gene, which is consistent with the biological function of its murine homologue. Also it inhibits nuclear translocation, transcriptional activation, and control of centrosome-duplication functions of p53. Recombinant human HSPA9 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

products references :

Xie H., et al. (2000) Leukemia. 14(12):2128-34. Deocaris CC., et al. (2007) Ann N Y Acad Sci. 1119:165-75.

ncbi gi num :

24234688

ncbi acc num :

NP_004125

ncbi gb acc num :

NM_004134.6

ncbi mol weight :

71 kDa (654 aa)

ncbi pathways :

Metabolism Of Proteins Pathway (106230); Mitochondrial Protein Import Pathway (576261); Parkin-Ubiquitin Proteasomal System Pathway (700638); RNA Degradation Pathway (117291); RNA Degradation Pathway (116127); Tuberculosis Pathway (213780); Tuberculosis Pathway (213743)

ncbi summary :

This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This protein is a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and maintenance of the mitochondria. A pseudogene of this gene is found on chromosome 2.[provided by RefSeq, May 2010]

uniprot summary :

HSPA9B: Implicated in the control of cell proliferation and cellular aging. May also act as a chaperone. Interacts with FXN. Interacts with HSCB. Component of the MINOS/MitOS complex, that includes IMMT, HSPA9 and CHCHD3 and associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2. Belongs to the heat shock protein 70 family. Protein type: Chaperone; Heat shock protein; Nucleolus. Chromosomal Location of Human Ortholog: 5q31.1. Cellular Component: focal adhesion; mitochondrion; cytoplasm; nucleolus. Molecular Function: protein binding; ubiquitin protein ligase binding; unfolded protein binding; ATP binding. Biological Process: cellular protein metabolic process; protein folding; protein export from nucleus; protein targeting to mitochondrion; negative regulation of apoptosis

size1 :

0.1 mg

price1 :

255 USD

size2 :

0.5 mg

price2 :

535

more info or order :

MyBioSource product webpage