catalog number :
MBS203182
products type :
Recombinant Protein
products full name :
Vasostatin 2, 19-131aa, Human, Recombinant, E Coli
products short name :
Vasostatin 2
products name syn :
Chromogranin A; Vasostatin 2; beta Granin; CGA; CHG A; CHGA; ChromograninA; Chromogranin A parathyroid secretory protein 1; Chromogranin A precursor; Pancreastatin; Parastatin; Parathyroid secretory protein 1; Pituitary secretory protein I; SP I; SP1; SPI; Vasostatin.
other names :
chromogranin-A isoform 1 preproprotein; Chromogranin-A; chromogranin-A; SP-I; betagranin (N-terminal fragment of chromogranin A); catestatin; chromofungin; parathyroid secretory protein 1; pituitary secretory protein I; chromogranin A (parathyroid secretory protein 1); Pituitary secretory protein I; SP-I
other gene names :
CHGA; CHGA; CGA; CgA; SP-I
uniprot entry name :
CMGA_HUMAN
sequence :
MLPVNSPMNK GDTEVMKCIV EVISDTLSKP SPMPVSQECF ETLRGDERIL SILRHQNLLK ELQDLALQGA KERAHQQKKH SGFEDELSEV LENQSSQAEL KEAVEEPSSK DVME
purity :
> 95% by SDS - PAGE
form :
Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
concentration :
1 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human
other info2 :
Expression System: E Coli. Endotoxin: < 1.0 Eu per 1 microgram of protein (determined by LAL method)
products categories :
Neuroscience
products description :
Vasostatin 2 is the N-terminal fragment (19-131 aa) derived from the cleavage of chromogranin A (CgA) which is a member of the chromogranin/secretogranin(granins) family of neuroendocrine secretory proteins. Vasostatin 2 has been shown to exert several biological activities on several tissues and organs and exerts a large spectrum of homeostatic actions, including antifungal and antimicrobial effect, modulation of cell adhesion, and inhibition of parathyroid hormone secretion. Recombinant human Vasostatin 2 protein was expressed in E.coli and purified by using conventional chromatography techniques.
products references :
Tota BW., et al. (2008). Curr Med Chem. 15(14):1444-51. Blois A., et al. (2006). Requl pept. 134(1):30-7.
ncbi gb acc num :
NM_001275.3
ncbi mol weight :
12.8 kDa (114aa), confirmed by MALDI-TOF.
ncbi summary :
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]