product summary
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company name :
MyBioSource
product type :
protein
product name :
Dopa decarboxylase, 1-480aa, Human, His tag, E Coli
catalog :
MBS203181
quantity :
0.1 mg
price :
310 USD
more info or order :
MyBioSource product webpage
image
image 1 :
MyBioSource MBS203181 image 1
product information
catalog number :
MBS203181
products type :
Recombinant Protein
products full name :
Dopa decarboxylase, 1-480aa, Human, His tag, E Coli
products short name :
[Dopa decarboxylase]
products name syn :
[DDC; AADC; Aromatic L-amino acid decarboxylase; L-Dopa decarboxylase; Aromatic L Amino Acid Decarboxylase]
other names :
[aromatic-L-amino-acid decarboxylase isoform 1; Aromatic-L-amino-acid decarboxylase; aromatic-L-amino-acid decarboxylase; dopa decarboxylase; DOPA decarboxylase; DDC]
other gene names :
[DDC; DDC; AADC; AADC; AADC; DDC]
host :
E Coli
sequence length :
480
sequence :
MGSSHHHHHH SSGLVPRGSH TRSMNASEFR RRGKEMVDYV ANYMEGIEGR QVYPDVEPGY LRPLIPAAAP QEPDTFEDII NDVEKIIMPG VTHWHSPYFF AYFPTASSYP AMLADMLCGA IGCIGFSWAA SPACTELETV MMDWLGKMLE LPKAFLNEKA GEGGGVIQGS ASEATLVALL AARTKVIHRL QAASPELTQA AIMEKLVAYS SDQAHSSVER AGLIGGVKLK AIPSDGNFAM RASALQEALE RDKAAGLIPF FMVATLGTTT CCSFDNLLEV GPICNKEDIW LHVDAAYAGS AFICPEFRHL LNGVEFADSF NFNPHKWLLV NFDCSAMWVK KRTDLTGAFR LDPTYLKHSH QDSGLITDYR HWQIPLGRRF RSLKMWFVFR MYGVKGLQAY IRKHVQLSHE FESLVRQDPR FEICVEVILG LVCFRLKGSN KVNEALLQRI NSAKKIHLVP CHLRDKFVLR FAICSRTVES AHVQRAWEHI KELAADVLRA ERE
purity :
> 95% by SDS-PAGE
form :
Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 2mM DTT, 10% glycerol.
concentration :
1 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
image1 heading :
SDS-Page
other info1 :
Antigen Species: Human. Tag Information: His-tag
products categories :
Neuroscience
products description :
Dopa decarboxylase, also known as DDC, is a homodimeric, pyridoxal phosphate dependent enzyme. Dopa decarboxylase is a protein implicated in 2 metabolic pathways, synthesizing 2 important neurotransmitters: dopamine and serotonin which both play key roles in many clinical disorders, including Parkinson's disease. Dopa decarboxylase is found in different areas of the brain and is particularly abundant in basal ganglia. Recombinant human Dopa decarboxylase protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography.
products references :
Avgeris M., et al. (2008). Clin Biochem. 41 (14-15):1140-9.; Pons R., et al. (2004). Neruology. 62 (7):1058-65.;
ncbi gi num :
132814448
ncbi acc num :
NP_001076440
ncbi gb acc num :
NM_001082971.1
uniprot acc num :
P20711
ncbi mol weight :
56.4 kDa (503aa), confirmed by MALDI-TOF.
ncbi pathways :
Alcoholism Pathway (585563); Alcoholism Pathway (587116); Amine-derived Hormones Pathway (1270175); Amino Acid Metabolism Pathway (1471249); Amphetamine Addiction Pathway (547607); Amphetamine Addiction Pathway (550546); Biogenic Amine Synthesis Pathway (198793); Catecholamine Biosynthesis Pathway (1270176); Catecholamine Biosynthesis, Tyrosine = Dopamine = Noradrenaline = Adrenaline Pathway (413357); Catecholamine Biosynthesis, Tyrosine = Dopamine = Noradrenaline = Adrenaline Pathway (468235)
ncbi summary :
The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2011]
uniprot summary :
Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
size1 :
0.1 mg
price1 :
310 USD
size2 :
0.5 mg
price2 :
720
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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