product summary
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company name :
MyBioSource
product type :
protein
product name :
Complexin1, 1-134aa, Human, His tag, Recombinant, E Coli
catalog :
MBS203173
quantity :
0.1 mg
price :
255 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS203173
products type :
Recombinant Protein
products full name :
Complexin1, 1-134aa, Human, His tag, Recombinant, E Coli
products short name :
Complexin1
products name syn :
CPXL1; CPX1; Synaphin-2; Complexin 1; Complexin I; CPX1; Synaphin 2
other names :
complexin-1; Complexin-1; complexin-1; CPX I; complexin I; synaphin 2; synaphin-2; complexin 1; Complexin I; CPX I; Synaphin-2
other gene names :
CPLX1; CPLX1; CPX1; CPX-I; CPX I
uniprot entry name :
CPLX1_HUMAN
sequence length :
134
sequence :
MGSSHHHHHH SSGLVPRGSH MEFVMKQALG GATKDMGKML GGDEEKDPDA AKKEEERQEA LRQAEEERKA KYAKMEAERE AVRQGIRDKY GIKKKEEREA EAQAAMEANS EGSLTRPKKA IPPGCGDEVE EEDESILDTV IKYLPGPLQD MLKK
purity :
> 90% by SDS - PAGE
form :
Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
concentration :
1 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human. Tag: His-tag
other info2 :
Expression System: E Coli. Endotoxin: < 1.0 Eu per 1 microgram of protein (determined by LAL method)
products categories :
Neuroscience
products description :
Complexin1 belongs to a family of SNARE complex binding proteins that were suggested to be either facilitators or inhibitors of vesicle exocytosis. Complexin 1 exhibits reduced Ca2+-triggered fast neurotransmitter release at hippocampal glutamatergic synapses, indicating that this protein is a positive regulator of transmitter release. In contrast, it inhibits SNARE-mediated liposome and cell fusions in vitro, which lead to the hypothesis that it acts as fusion clamps of synaptic exocytosis. Recombinant Complexin 1 protein was expressed in E.coli and purified by using conventional chromatography techniques.
products references :
Salimi K, et al. (2008) Synapse, 273-82. Giraudo CG, et al. (2006) Science, 676-80. Tang J, et al. (2006) Cell, 1175-87.
ncbi gi num :
5729781
ncbi acc num :
NP_006642
ncbi gb acc num :
NM_006651.3
ncbi mol weight :
17.1 kDa (154 aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher)
ncbi pathways :
Acetylcholine Neurotransmitter Release Cycle Pathway 106525!!Dopamine Neurotransmitter Release Cycle Pathway 106523!!GABA Synthesis, Release, Reuptake And Degradation Pathway 187174!!Glutamate Neurotransmitter Release Cycle Pathway 106522!!Neuronal System Pathway 106513!!Neurotransmitter Release Cycle Pathway 106518!!Norepinephrine Neurotransmitter Release Cycle Pathway 106519!!Serotonin Neurotransmitter Release Cycle Pathway 106520!!Synaptic Vesicle Pathway 672457!!Synaptic Vesicle Cycle Pathway 373900
ncbi summary :
Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. [provided by RefSeq, Jul 2008]
size :
0.1 mg
price :
255 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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