product summary
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company name :
MyBioSource
product type :
protein
product name :
VAMP8, 1-76aa, Human, His tag, Recombinant, E Coli
catalog :
MBS203171
quantity :
0.1 mg
price :
375 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS203171
products type :
Recombinant Protein
products full name :
VAMP8, 1-76aa, Human, His tag, Recombinant, E Coli
products short name :
VAMP8
products name syn :
Endobrevin; EDB; VAMP8; Vesicle-associated membrane protein 8; Vesicle-associated membrane protein 8 VAMP 5; VAMP 8; VAMP-8; VAMP5; Vesicle associated membrane protein 8.
other names :
vesicle-associated membrane protein 8; Vesicle-associated membrane protein 8; vesicle-associated membrane protein 8; vesicle-associated membrane protein 8 (endobrevin); vesicle-associated membrane protein 8; Endobrevin; EDB
products gene name :
VAMP8
other gene names :
VAMP8; VAMP8; EDB; VAMP-8; VAMP-8; EDB
uniprot entry name :
VAMP8_HUMAN
sequence length :
100
sequence :
MGSSHHHHHH SSGLVPRGSH MEEASEGGGN DRVRNLQSEV EGVKNIMTQN VERILARGEN LEHLRNKTED LEATSEHFKT TSQKVARKFW WKNVKM
purity :
> 85% by SDS PAGE
form :
Liquid in 20mM Tris pH8.0, 0.1mM PMSF, 0.2M NaCl, 50% glycerol
concentration :
0.25mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human. Tag: His-tag
other info2 :
Expression System: E Coli
products categories :
Neuroscience
products description :
Vehicle-associated membrane (VAMP8),also known as endobrevin, is the main components of a SNARE complex involved in the docking and fusion of synaptic vesicles with the presynaptic membrane. This protein plays a role in regulated enzyme secretion in pancreatic acinar cells and is involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. It is required for dense-granule secretion in platelets. Recombinant VAMP8 protein was expressed in E.coli and purified by using conventional chromatography techniques.
products references :
Polgar J., et al. (2002) Blood. 100(3):1081-3. Ren Q., et al. (2007) Mol Biol Cell. 18(1):24-33.
ncbi gi num :
14043026
ncbi acc num :
NP_003752
ncbi gb acc num :
NM_003761.4
ncbi mol weight :
10.9kDa (96aa), confirmed by MALDI-TOF.
ncbi pathways :
Clathrin Derived Vesicle Budding Pathway (119545); Golgi Associated Vesicle Biogenesis Pathway (119546); Lysosome Vesicle Biogenesis Pathway (119547); Membrane Trafficking Pathway (106160); Platelet Activation Pathway (952858); SNARE Interactions In Vesicular Transport Pathway (83057); SNARE Interactions In Vesicular Transport Pathway (467); Trans-Golgi Network Vesicle Budding Pathway (106165)
ncbi summary :
This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated membrane protein subfamily of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The encoded protein is involved in the fusion of synaptic vesicles with the presynaptic membrane.[provided by RefSeq, Jun 2010]
uniprot summary :
VAMP8: Involved in the targeting and/or fusion of transport vesicles to their target membrane. Involved for dense-granule secretion in platelets. Plays a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes. Belongs to the synaptobrevin family. Protein type: Membrane protein, integral; Vesicle. Chromosomal Location of Human Ortholog: 2p12-p11.2. Cellular Component: cell surface; mitochondrion; late endosome membrane; lysosomal membrane; secretory granule membrane; early endosome; integral to membrane; cytosol; SNARE complex; recycling endosome; membrane; perinuclear region of cytoplasm; cytoplasm; plasma membrane; vesicle. Molecular Function: SNAP receptor activity; protein binding; SNARE binding; chloride channel inhibitor activity; syntaxin binding. Biological Process: vesicle fusion; protein transport; entry of virus into host cell; exocytosis; autophagic vacuole fusion; regulation of endocytosis; neutrophil degranulation; eosinophil degranulation; endocytosis; post-Golgi vesicle-mediated transport
size1 :
0.1 mg
price1 :
375 USD
size2 :
0.5 mg
price2 :
925
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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