protein

Recombinant Neuromedin U (NMU)

MBS2031674

0.01 mg

140 USD

Recombinant Protein

Recombinant Neuromedin U (NMU)

[Neuromedin U]

[neuromedin U; Neuromedin-U; neuromedin-U; neuromedin U]

[NMU]

[NMU; NMU; NmU-25]

NMU_HUMAN

E Coli

> 95%

Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.

Original Concentration: 200 ug/mL

Storage: Avoid repeated freeze/thaw cycles. Store at 2-8ºC for one month. Aliquot and store at -80ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Positive Control; Immunogen; SDS-PAGE;Western Blot (WB). (May be suitable for use in other assays to be determined by the end user.)

SDS-Page

Testing Data (TD)

Organism Species: Rattus norvegicus (Rat). Source: Prokaryotic expression. Residues: Cys38~Ile174 (Accession # P12760). Tags: N-terminal His Tag. Subcellular Location: Secreted. Traits: Freeze-dried powder. Buffer formulation: 20mM Tris, 150mM NaCl, pH8.0, containing 0.01% SKL, 5% Trehalose

Predicted isoelectric point: 10.0. Predicted Molecular Mass: 19.6kDa. Accurate Molecular Mass: 16kDa as determined by SDS-PAGE reducing conditions. Usage: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

609013

CAA53619.1

P48645

Class A/1 (Rhodopsin-like Receptors) Pathway (1269545); G Alpha (i) Signalling Events Pathway (1269576); G Alpha (q) Signalling Events Pathway (1269578); GPCR Downstream Signaling Pathway (1269574); GPCR Ligand Binding Pathway (1269544); Gastrin-CREB Signalling Pathway Via PKC And MAPK (1269592); Peptide Ligand-binding Receptors Pathway (1269546); Signal Transduction Pathway (1269379); Signaling By GPCR Pathway (1269543)

This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in pain, stress, immune-mediated inflammatory diseases and feeding regulation. Increased expression of this gene was observed in renal, pancreatic and lung cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. Some of these isoforms may undergo similar processing to generate the mature peptide. [provided by RefSeq, Jul 2015]

NMU: Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder. Belongs to the NmU family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 4q12. Cellular Component: extracellular region; terminal button. Molecular Function: neuromedin U receptor binding; receptor binding. Biological Process: regulation of smooth muscle contraction; gastric acid secretion; G-protein coupled receptor protein signaling pathway; neuropeptide signaling pathway; eating behavior; photoperiodism; digestion; positive regulation of hormone secretion; positive regulation of smooth muscle contraction; signal transduction; sensory perception of pain; positive regulation of synaptic transmission

0.01 mg

140 USD

0.05 mg

260

0.1 mg

400

0.2 mg

490

0.5 mg

950

1 mg

1405